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Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.
Results suggest that ING2 acts as a tumor suppressor in osteosarcoma.
It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.
Decreased expression of ING2 gene is associated with non-small cell lung cancer.
It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer.
findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites
Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men.
Data show that inhibition of ING2 expression accelerates progression of cells from G(1) to S-phase, and is accompanied by a decrease of p21 (show CDKN1A Proteins) expression, and that regulation of p21 (show CDKN1A Proteins) by ING2 is independent of p53 (show TP53 Proteins).
sumoylation of ING2 enhances its binding to the Sin3A (show SIN3A Proteins)/HDAC (show HDAC3 Proteins) complex and is required to regulate gene transcriptions
ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation.
These findings define a novel function for ING2 in muscle differentiation.
2.0 A resolution structure of the mouse ING2 PHD (show PDC Proteins) finger in complex with a histone H3 (show HIST3H3 Proteins) peptide trimethylated at lysine 4
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.
inhibitor of growth family, member 2
, inhibitor of growth family, member 1-like
, inhibitor of growth family, X-linked, pseudogene
, inhibitor of growth 1-like protein
, inhibitor of growth protein 2