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study suggests that miR (show MLXIP Proteins)-155 plays a host-damaging role during dextran sulfate sodium-induced colitis mice and induces Th17 differentiation by targeting Jarid2
JARID2 physically interacts with ESRRB, SALL4A (show SALL4 Proteins), and PRDM14 (show PRDM14 Proteins)
ESCs (show NR2E3 Proteins) lacking Jarid2 show constitutive Nanog (show NANOG Proteins) expression, reduced PCP (show BMP1 Proteins)/Wnt (show WNT2 Proteins) signaling and form more than one ICM upon injection to E3.5 mouse blastocysts.
Jarid2 is a novel player in iNKT cell maturation that regulates PLZF (show ZBTB16 Proteins) expression by modulating H3K9 methylation
Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function
miR (show MLXIP Proteins)-155 regulates the fate of Th17 and Treg cells and miR (show MLXIP Proteins)-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2.
Data indicate that upon stimulation of muscle cells with IFN-gamma (show IFNG Proteins), JARID2 and other members of the Polycomb (show CBX2 Proteins) repressive complex 2 (PRC2) were recruited to promoters to repress myogenesis.
Jarid2 exhibits nucleosome-binding activity that contributes to PRC2 stimulation
Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 (show NOTCH1 Proteins) expression via histone modification in the developing heart.
these studies identify JARID2, MTF2 (show MTF2 Proteins), and esPRC2p48 as important regulatory subunits of PRC2 in ES cells and reveal critical functions of these subunits
JARID2 plays an important role in glioma development.
Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility.
JARID2 inhibits leukemia cell proliferation by regulating CCND1 (show CCND1 Proteins) expression
TGF-ss-dependent expression changes of EMT (show ITK Proteins)-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression.
Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb (show CBX2 Proteins) repressive complex 2 (PRC2) activity depending on the chromatin context.
Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2.
The interaction of JARID2 at these promoters is dependent on EED (show EED Proteins).
Jarid2 is an important mediator of Xist-induced PRC2 targeting.
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.
jumonji, AT rich interactive domain 2
, jumonji, AT rich interactive domain 2 protein
, protein Jumonji-like
, jumonji/ARID domain-containing protein 2
, protein Jumonji
, jumonji homolog
, jumonji-like protein