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In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC (show FAM126A ELISA Kits) and better survival.
Preeclamptic plasma induces transcription modifications involving the AP-1 (show FOSB ELISA Kits) transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
the recruitment of multiple HDAC (show HDAC3 ELISA Kits) members to JDP2 and ATF3 (show ATF3 ELISA Kits) is part of their transcription repression mechanism.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
JDP2 is crucial to triggering reactivation from latency to lytic replication
JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
JDP2 acts as a repressor and could be functionally associated with HDAC3 (show HDAC3 ELISA Kits) to inhibit CHOP (show DDIT3 ELISA Kits) transcription
Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH (show BRD2 ELISA Kits) and higher expression of the Fshb (show FSHB ELISA Kits) subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles
JDP2 acts as a novel transcriptional activator of the mouse Mc2r (show MC2R ELISA Kits) gene, suggesting that JDP2 may have physiological functions as a novel player in MC2R (show MC2R ELISA Kits)-mediated steroidogenesis as well as cell signaling in adrenal glands.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
results suggest a negative feedback loop between JDP2 and p53 (show TP53 ELISA Kits), and a direct link between JDP2 and a key oncogenic pathway
Tbx3 (show TBX3 ELISA Kits) plays an important role in osteoclastogenesis at least in part by regulating CSF1 (show CSF1 ELISA Kits)-dependent expression of JDP2.
Using transgenic mice overexpressing the AP-1 (show JUN ELISA Kits) inhibitor JDP2, a central role of AP-1 (show JUN ELISA Kits) in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated.
Jdp2 transcriptionally regulates the Trp53 (show TP53 ELISA Kits) promoter, via an atypical AP-1 (show JUN ELISA Kits) site, and Jdp2 expression negatively regulates Trp53 (show TP53 ELISA Kits) expression levels; a genetic mechanism for tumour formation in the context of Trp53 (show TP53 ELISA Kits) heterozygosity
Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation.
JDP2 phosphorylation by JNK (show MAPK8 ELISA Kits) results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli
the kinase fragment of DCLK (show DCLK2 ELISA Kits) is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Jun dimerization protein 2
, jun dimerization protein 2
, progesterone receptor co-activator
, c-Jun dimerization protein 2