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This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 (show WDR5 ELISA Kits) and KAT2A complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
To understand how Gcn5 discriminates between different acyl-CoA molecules, structures of the catalytic domain of human Gcn5L2 bound to propionyl-CoA and butyryl-CoA were determined.
Data suggest that expression of GCN5 (histone acetyltransferase GCN5) is induced in skeletal muscle during a 48-hour fast; in contrast, expression of SIRT1 (sirtuin 1 (show SIRT1 ELISA Kits)) remains unchanged.
Orc5 associates with the H3 histone acetyl transferase GCN5 (also known as KAT2A), and this association enhances the chromatin-opening function of Orc5.
Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.
these results may point to the GCN5-NF-kappaB (show NFKB1 ELISA Kits) pathway as a novel potential molecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis.
Acetyltransferase p300 (show EP300 ELISA Kits) collaborates with chromodomain helicase DNA-binding protein 4 (CHD4 (show CHD4 ELISA Kits)) to facilitate DNA double-strand break repair
Suggest lysine acetyltransfer as a potential regulator of platelet actin dynamics, and potential roles for lysine acetylation in the molecular coordination of platelet activation and function.
Data uncover GCN5 as a negative regulator of C/EBPalpha (show CEBPA ELISA Kits) and demonstrate the importance of C/EBPalpha (show CEBPA ELISA Kits) acetylation in myeloid differentiation.
GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 (show STAT3 ELISA Kits) and AKT (show AKT1 ELISA Kits) Signaling Pathways
recovering GCN5 expression in vivo by lentiviral expression vector significantly attenuated the loss of angiogenesis in ovariectomized mouse femurs
study reveals previously unknown physiological functions for Gcn5 and a molecular mechanism underlying these functions in regulating T cell immunity; Gcn5 may be an important new target for autoimmune disease therapy
Together, our experiments identify a novel nonhistone substrate of GCN5, highlight an essential role for both GCN5 and RA signaling in early diencephalic development, and elucidate a novel molecular regulatory mechanism for RA signaling that is specific to the developing forebrain.
In addition to reducing atrogene expression, surprisingly inhibiting NF-kappaB (show NFKB1 ELISA Kits) with IkappaBalpha (show NFKBIA ELISA Kits)-SR or by GCN5 knockdown in these muscles also enhanced AKT (show AKT1 ELISA Kits) and mechanistic target of rapamycin (mTOR (show FRAP1 ELISA Kits)) activities, which also contributed to the reduction in atrophy.
Gcn5 and PCAF (show KAT2B ELISA Kits) repress IFN-beta (show IFNB1 ELISA Kits) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (show TBK1 ELISA Kits) in the cytoplasm.
GCN5 and HDAC1 (show HDAC1 ELISA Kits) are the crucial enzymes that regulating epigenetic reprogramming; we observed dynamic changes in the expression levels of GCN5 and HDAC1 (show HDAC1 ELISA Kits) during embryo development
In conclusion, these data establish Kat2a as a novel and essential regulator of hippocampal memory consolidation.
Study reveals that Gcn5/PCAF (show KAT2B ELISA Kits) facilitate adipogenesis through regulation of PPARgamma (show PPARG ELISA Kits) expression and regulate brown adipogenesis by influencing Prdm16 (show PRDM16 ELISA Kits) expression.
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009
histone acetyltransferase KAT2A
, general control of amino acid synthesis 5-like 2
, GCN5 general control of amino-acid synthesis 5-like 2
, general control of amino acid synthesis protein 5-like 2
, K(lysine) acetyltransferase 2A
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
, General control of amino acid synthesis, yeast, homolog-like 2
, histone acetyltransferase GCN5
, lysine acetyltransferase 2A
, GCN5 general control of amino acid synthesis-like 2
, general control of amino acid synthesis, yeast homolog-like 2
, general control of amino acid synthesis-like 2