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anti-Mouse (Murine) L3MBTL1 Antibodies:
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Human Polyclonal L3MBTL1 Primary Antibody for IHC - ABIN966472
Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. in Oncogene 1999
Show all 5 Pubmed References
Human Polyclonal L3MBTL1 Primary Antibody for IHC - ABIN966471
Bechtel, Rosenfelder, Duda, Schmidt, Ernst, Wellenreuther, Mehrle, Schuster, Bahr, Blöcker, Heubner, Hoerlein, Michel, Wedler, Köhrer, Ottenwälder, Poustka, Wiemann, Schupp: The full-ORF clone resource of the German cDNA Consortium. in BMC genomics 2008
Show all 5 Pubmed References
Human Polyclonal L3MBTL1 Primary Antibody for WB - ABIN2668237
Qin, Van Buren, Huang, Zhong, Mostoslavsky, Akbarian, Hock: Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. in The Journal of biological chemistry 2010
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L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms.
generation and analysis of mice after disruption of L3MBTL1
Loss of the paternally derived allele of the imprinted L3MBTL1 gene is associated with Shwachman-Diamond syndrome.
The polycomb group protein L3MBTL1 represses a SMAD5 (show SMAD5 Antibodies)-mediated hematopoietic transcriptional program in human pluripotent stem cells.
High expression of L3MBTL1 was associated with low grade and hormone receptor (show NR4A1 Antibodies)-positive tumors, as well as low risk of disease recurrence and breast cancer death.
depletion of L3MBTL1 does not affect hESC self-renewal, rather it enhances differentiation toward extra-embryonic trophoblast tissues
Data suggest that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.
SET8 (show SETD8 Antibodies)-mediated methylation of p53 (show TP53 Antibodies) at Lys (show LYZ Antibodies)-382 promotes the interaction between L3MBTL1 and p53 (show TP53 Antibodies) in cells.
haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera (show IGF2BP3 Antibodies), by promoting erythroid differentiation
The ability of TEL (show ETV6 Antibodies) to repress TEL (show ETV6 Antibodies)-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL (show ETV6 Antibodies) interacting domains, which are mapped to their respective SPM (show NPC1 Antibodies)/SAM (show TTN Antibodies) domains.
represents a previously undescribed imprinted locus, a vertebrate Polycomb (show CBX2 Antibodies) group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions
L3MBTL may have a role in myeloid leukemia (show BCL11A Antibodies)
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, L(3)mbt protein homolog
, lethal(3)malignant brain tumor-like protein 1
, l(3)mbt protein homolog
, lethal (3) malignant brain tumor l(3)
, L(3)malignant brain tumor-like protein