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L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms.
generation and analysis of mice after disruption of L3MBTL1
The polycomb group protein L3MBTL1 represses a SMAD5 (show SMAD5 Proteins)-mediated hematopoietic transcriptional program in human pluripotent stem cells.
High expression of L3MBTL1 was associated with low grade and hormone receptor (show NR4A1 Proteins)-positive tumors, as well as low risk of disease recurrence and breast cancer death.
depletion of L3MBTL1 does not affect hESC self-renewal, rather it enhances differentiation toward extra-embryonic trophoblast tissues
Data suggest that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.
SET8 (show SETD8 Proteins)-mediated methylation of p53 (show TP53 Proteins) at Lys (show LYZ Proteins)-382 promotes the interaction between L3MBTL1 and p53 (show TP53 Proteins) in cells.
haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera (show IGF2BP3 Proteins), by promoting erythroid differentiation
The ability of TEL (show ETV6 Proteins) to repress TEL (show ETV6 Proteins)-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL (show ETV6 Proteins) interacting domains, which are mapped to their respective SPM (show NPC1 Proteins)/SAM (show TTN Proteins) domains.
represents a previously undescribed imprinted locus, a vertebrate Polycomb (show CBX2 Proteins) group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions
L3MBTL may have a role in myeloid leukemia (show BCL11A Proteins)
The MBT domain is related to protein domains that directly bind methylated histone residues and study found that L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26.
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
, L(3)mbt protein homolog
, lethal(3)malignant brain tumor-like protein 1
, l(3)mbt protein homolog
, lethal (3) malignant brain tumor l(3)
, L(3)malignant brain tumor-like protein