Browse our L3MBTL1 Proteins (L3MBTL1)

Full name:
L(3)mbt-Like 1 (Drosophila) Proteins (L3MBTL1)
On www.antibodies-online.com are 4 L(3)mbt-Like 1 (Drosophila) (L3MBTL1) Proteins from 3 different suppliers available. Additionally we are shipping L3MBTL1 Antibodies (37) and many more products for this protein. A total of 46 L3MBTL1 products are currently listed.
Synonyms:
C630004G01, dJ138B7.3, H-L(3)MBT, L3MBTL, mKIAA0681, RGD1307316, ZC2HC3
list all proteins Gene Name GeneID UniProt
L3MBTL1 241764 A2A5N8
L3MBTL1 26013 Q9Y468
Rat L3MBTL1 L3MBTL1 311613 D3ZWK4

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L3MBTL1 Proteins (L3MBTL1) by Origin

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More Proteins for L3MBTL1 Interaction Partners

Mouse (Murine) L(3)mbt-Like 1 (Drosophila) (L3MBTL1) interaction partners

  1. L3mbtl1 loss-of-function was associated with significant decreases in depression and and anxiety in some of the behavioral paradigms.

  2. generation and analysis of mice after disruption of L3MBTL1

Human L(3)mbt-Like 1 (Drosophila) (L3MBTL1) interaction partners

  1. Loss of the paternally derived allele of the imprinted L3MBTL1 gene is associated with Shwachman-Diamond syndrome.

  2. The polycomb group protein L3MBTL1 represses a SMAD5 (show SMAD5 Proteins)-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  3. High expression of L3MBTL1 was associated with low grade and hormone receptor (show NR4A1 Proteins)-positive tumors, as well as low risk of disease recurrence and breast cancer death.

  4. depletion of L3MBTL1 does not affect hESC self-renewal, rather it enhances differentiation toward extra-embryonic trophoblast tissues

  5. Data suggest that the loss of L3MBTL1 contributes to the development of 20q(-) hematopoietic malignancies by inducing replicative stress, DNA damage, and genomic instability.

  6. SET8 (show SETD8 Proteins)-mediated methylation of p53 (show TP53 Proteins) at Lys (show LYZ Proteins)-382 promotes the interaction between L3MBTL1 and p53 (show TP53 Proteins) in cells.

  7. haploinsufficiency of L3MBTL1 contributes to some (20q-) myeloproliferative neoplasms, especially polycythemia vera (show IGF2BP3 Proteins), by promoting erythroid differentiation

  8. The ability of TEL (show ETV6 Proteins) to repress TEL (show ETV6 Proteins)-responsive promoters is enhanced by the presence of H-L(3)MBT, an effect dependent on the H-L(3)MBT and the TEL (show ETV6 Proteins) interacting domains, which are mapped to their respective SPM (show NPC1 Proteins)/SAM (show TTN Proteins) domains.

  9. represents a previously undescribed imprinted locus, a vertebrate Polycomb (show CBX2 Proteins) group gene shown to be regulated by this mechanism, and has implications for the pathogenesis of myeloid malignancies associated with 20q deletions

  10. L3MBTL may have a role in myeloid leukemia (show BCL11A Proteins)

L3MBTL1 Protein Profile

Protein Summary

This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with L3MBTL1

  • l(3)mbt-like (Drosophila) (L3mbtl1)
  • l(3)mbt-like 1 (Drosophila) (L3MBTL1)
  • l(3)mbt-like 1 (Drosophila) (L3mbtl1)
  • C630004G01 protein
  • dJ138B7.3 protein
  • H-L(3)MBT protein
  • L3MBTL protein
  • mKIAA0681 protein
  • RGD1307316 protein
  • ZC2HC3 protein

Protein level used designations for L3MBTL1

H-l(3)mbt protein , L(3)mbt protein homolog , lethal(3)malignant brain tumor-like protein 1 , l(3)mbt protein homolog , lethal (3) malignant brain tumor l(3) , L(3)malignant brain tumor-like protein

GENE ID SPECIES
241764 Mus musculus
26013 Homo sapiens
529298 Bos taurus
419115 Gallus gallus
311613 Rattus norvegicus
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