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Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1 (show TAL1 Proteins)/LMO2/LDB1 (show LDB1 Proteins) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
DNM2 (show DNM2 Proteins) mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 (show IL7 Proteins) signalling.
Hhex (show HHEX Proteins) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
HHEX (show HHEX Proteins) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
GATA2 (show GATA2 Proteins) and Lmo2 cooperatively regulate VEGF (show VEGFA Proteins)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Proteins).
a regulatory hierarchy of HOX (show MSH2 Proteins) control of LMO2 in normal development
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.
Studied the solution structure of Lmo2(LIM2 (show LHX2 Proteins)) /Ldb1 (show LDB1 Proteins)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 Proteins) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 Proteins) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.
Studies demonstrate that Etv2 (show ETV2 Proteins) is expressed during and required for yolk sac (show ADCY10 Proteins) hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2 (show ETV2 Proteins).
This article demonstrates a novel and unexpected function of the LMO2 oncogenic transcription factor in controlling DNA replication that we unravelled via an unbiased proteome-wide screen for LMO2-interacting partners.
Findings suggest that LMO2 loss may be a good predictor for the presence of MYC (show MYC Proteins) translocation in large B-cell lymphoma.
FOXP3 (show FOXP3 Proteins) binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1 (show TAL1 Proteins), providing a molecular mechanism for FOXP3 (show FOXP3 Proteins)-mediated transcriptional modulation in T-ALL.
recurrent activating intronic mutations of LMO2, a prominent oncogene (show RAB1A Proteins) in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples.
Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells.
we demonstrate previously unrecognized mechanisms by which LMO2 alters human T-cell development in vivo; these mechanisms correlate with human T-ALL leukemogenesis.
this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6 (show UBA6 Proteins)-USE1-FAT10ylation pathway by targeting the E1 enzyme (show ENOPH1 Proteins) UBA6 (show UBA6 Proteins).
LMO2 is a useful marker for immunophenotypic assessment of thymic neoplasms.
LMO2 was associated with increased levels of cytosolic p27(Kip1 (show CDKN1B Proteins)) protein.
that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival.
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 Proteins)-Lmo2-induced haemangioblasts differentiate into endothelial cells
Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.
Scl (show TAL1 Proteins)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
, LIM domain only 2 (rhombotin-like 1)
, LIM domain only protein 2
, LIM only 2
, T-cell translocation protein 2
, cysteine-rich protein TTG-2
, T-cell translocation gene 2
, rhombotin 2
, rhombotin-like 1
, LIM domain only-2