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LRWD1 is a novel regulator of EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) driven cell proliferation in Ewing sarcoma cells. EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) regulates LRWD1 expression and LRWD1 may contribute to EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) mediated transcriptional repression.
Data show that ORCA acts as a scaffold for the establishment of H3K9 KMT (show CAMKMT Proteins) complex.
This is the first study showing that the expression of the testis-enriched LRWD1 gene is regulated by NF-kappaB (show NFKB1 Proteins).
Data (from studies using recombinant proteins) suggest that deletion of leucine rich (LRR) domain significantly down-regulates expression of LRWD1 protein; LRR domain is significantly correlated with stability of LRWD1 protein.
three coding single-nucleotide polymorphisms (SNP1 (show SNRNP70 Proteins)-SNP3) could be detected in Japanese patients with Sertoli cell-only syndrome
Orc2 protects ORCA from ubiquitin-mediated degradation in vivo.
propose that the dynamic association of ORCA with pre-RC components modulates the assembly of its interacting partners on chromatin and facilitates DNA replication initiation
Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 (show HIST3H3 Proteins) and maintains heterochromatin silencing
Results suggest ORCA-mediated association of ORC to chromatin is critical to initiate preRC assembly in G1 and chromatin organization in post-G1 cells.
immunostaining and immunoprecipitation showed colocalization and interaction between lrwd1 and gamma-tubulin (show TUBG1 Proteins) respectively, implicating lrwd1 as a candidate centrosomal protein. These results suggest that lrwd1 may play an important role in spermatogenesis.
Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells (By similarity).
leucine-rich repeats and WD repeat domain containing 1
, leucine-rich repeat and WD repeat-containing protein 1
, ORC-associated protein
, Origin recognition complex-associated protein
, centromere protein 33
, origin recognition complex associated
, origin recognition complex-associated protein