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CpG and methylation-dependent DNA binding and dynamics of the MBD2 (show DPEP2 ELISA Kits) protein at the single-molecule level have been reported.
Results show that MBD2 (show DPEP2 ELISA Kits) mediates epigenetic silencing of Htra1 (show HTRA1 ELISA Kits).
MBD2 (show DPEP2 ELISA Kits) has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
MBD2 (show DPEP2 ELISA Kits) expression was elevated in HCC (show FAM126A ELISA Kits) tissue, which suggesting MBD2 (show DPEP2 ELISA Kits) as a candidate prognostic marker of HCC (show FAM126A ELISA Kits).
downregulation of miR (show MLXIP ELISA Kits)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (show DPEP2 ELISA Kits) in the human OSCC cell line UM1.
Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 ELISA Kits) domain and MBD2 (show DPEP2 ELISA Kits) C-terminus.
MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
The dynamics of MBD2 (show DPEP2 ELISA Kits) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.
Data suggest that MBD2 (show DPEP2 ELISA Kits) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (show DPEP2 ELISA Kits) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (show DPEP2 ELISA Kits) for methylated DNA.
It has been shown that chromatin localization of Mbd2 and Mbd3 (show MBD3 ELISA Kits) is highly overlapping, and both proteins are interdependent for chromatin association.
MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
Loss of Mbd2 resulted in impaired implementation of above DNA methylation (show HELLS ELISA Kits) changes associated with altered energy homeostasis, which then protected mice from HFD-induced obesity and insulin (show INS ELISA Kits) resistance.
Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.
methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (show HLX ELISA Kits).
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.
miR (show MLXIP ELISA Kits)-290/371-Mbd2-Myc (show MYC ELISA Kits) circuit regulates glycolytic metabolism to promote pluripotency.
these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (show SCN3A ELISA Kits) expression during postnatal development and seizure condition.
Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (show AMD1 ELISA Kits)).
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
methyl-CpG binding domain protein 2
, methyl-CpG-binding domain protein 2
, methyl-CpG-binding protein MBD2
, methyl-CpG binding protein MBD2