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Overexpression of MBD3 is associated with neoplasms.
Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes.
This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 ELISA Kits)) gene polymorphisms and schizophrenia.
These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms
reduced mRNA expression of MBD2 (show DPEP2 ELISA Kits) and MBD3 is implicated in gastric carcinogenesis.
MBD3 is enriched at active promoters, whereas MBD2 (show DPEP2 ELISA Kits) is bound at methylated promoters and enriched at exon sequences of active genes.
These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2).
MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome.
MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma
interaction with two highly related p66 (show POLD3 ELISA Kits) proteins
Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 (show DEFB103A ELISA Kits) in embryonic orofacial cells.
Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.
overexpression facilitates NANOG-mediated reprogramming in neural stem cells
Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 ELISA Kits) and POLB (show POLB ELISA Kits) as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos.
cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 ELISA Kits)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt (show WNT2 ELISA Kits) signaling genes
Study finds that Mbd3 and Brg1 (show SMARCA4 ELISA Kits) antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 (show SMARCA4 ELISA Kits) play key roles in the biology of 5-hydroxymethylcytosine.
the transactivation domain of c-Jun (show JUN ELISA Kits) recruits Mbd3/NuRD to AP-1 (show JUN ELISA Kits) target genes to mediate gene repression, and this repression is relieved by JNK (show MAPK8 ELISA Kits)-mediated c-Jun (show JUN ELISA Kits) N-terminal phosphorylation
Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells
MBD3 protein is differentially expressed in principal neurons of the hippocampus and cortex, and in the adult retina.
MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2 (show MBD2 ELISA Kits)-MeCP1-mediated methylation silencing
Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.
methyl-CpG binding domain protein 3
, methyl-CpG binding protein MBD3 long form
, methyl-CpG-binding domain protein 3
, methyl-CpG-binding protein MBD3