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Methyl-CpG Binding Domain Protein 3 ELISA Kits (MBD3)
On www.antibodies-online.com are 1 Methyl-CpG Binding Domain Protein 3 (MBD3) ELISA Kits from 1 different suppliers available. Additionally we are shipping MBD3 Antibodies (108) and MBD3 Proteins (7) and many more products for this protein. A total of 122 MBD3 products are currently listed.
Synonyms:
AI181826, AU019209, DKFZp459N1635, MBD3, MGC69548, xmbd3
list all ELISA KIts Gene Name GeneID UniProt
MBD3 53615 O95983
MBD3 17192 Q9Z2D8
Rat MBD3 MBD3 362834  

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Human Methyl-CpG Binding Domain Protein 3 (MBD3) interaction partners

  1. MBD3 inhibits epithelial-mesenchymal transition in pancreatic cancer cells probably via TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling and may be a candidate for diagnostics and prognosis of pancreatic cancer.

  2. Overexpression of MBD3 is associated with neoplasms.

  3. Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes.

  4. This study investigates the genetic association between methyl-CpG-binding domain (MBD (show DPEP1 ELISA Kits)) gene polymorphisms and schizophrenia.

  5. These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms

  6. reduced mRNA expression of MBD2 (show DPEP2 ELISA Kits) and MBD3 is implicated in gastric carcinogenesis.

  7. MBD3 is enriched at active promoters, whereas MBD2 (show DPEP2 ELISA Kits) is bound at methylated promoters and enriched at exon sequences of active genes.

  8. These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2).

  9. MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome.

  10. MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma

Mouse (Murine) Methyl-CpG Binding Domain Protein 3 (MBD3) interaction partners

  1. Smek/Mbd3 interaction regulates neuronal gene expression and neuronal differentiation during cortical development.

  2. This work revealed the critical function of miR (show MLXIP ELISA Kits)-134-Mbd3 axis on regulating reprogramming and pluripotency of induced pluripotent stem cells derived from the neural progenitor cells.

  3. Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 (show DEFB103A ELISA Kits) in embryonic orofacial cells.

  4. Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.

  5. overexpression facilitates NANOG-mediated reprogramming in neural stem cells

  6. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 ELISA Kits) and POLB (show POLB ELISA Kits) as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos.

  7. cyclin-dependent kinase 2-associated protein 1 (CDK2AP1 (show CDK2AP1 ELISA Kits)), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt (show WNT2 ELISA Kits) signaling genes

  8. Study finds that Mbd3 and Brg1 (show SMARCA4 ELISA Kits) antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 (show SMARCA4 ELISA Kits) play key roles in the biology of 5-hydroxymethylcytosine.

  9. the transactivation domain of c-Jun (show JUN ELISA Kits) recruits Mbd3/NuRD to AP-1 (show JUN ELISA Kits) target genes to mediate gene repression, and this repression is relieved by JNK (show MAPK8 ELISA Kits)-mediated c-Jun (show JUN ELISA Kits) N-terminal phosphorylation

  10. Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells

MBD3 Antigen Profile

Antigen Summary

Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing.

Alternative names and synonyms associated with MBD3

  • methyl-CpG binding domain protein 3 (mbd3) Elisa Kit
  • methyl-CpG binding domain protein 3 (MBD3) Elisa Kit
  • methyl-CpG binding domain protein 3 (Mbd3) Elisa Kit
  • AI181826 Elisa Kit
  • AU019209 Elisa Kit
  • DKFZp459N1635 Elisa Kit
  • MBD3 Elisa Kit
  • MGC69548 Elisa Kit
  • xmbd3 Elisa Kit

Protein level used designations for MBD3

methyl-CpG binding domain protein 3 , methyl-CpG binding protein MBD3 long form , methyl-CpG-binding domain protein 3 , methyl-CpG-binding protein MBD3

GENE ID SPECIES
398135 Xenopus laevis
448748 Xenopus (Silurana) tropicalis
455554 Pan troglodytes
100172033 Pongo abelii
53615 Homo sapiens
17192 Mus musculus
362834 Rattus norvegicus
770153 Gallus gallus
485080 Canis lupus familiaris
616090 Bos taurus
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