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anti-Human MBD6 Antibodies:
anti-Mouse (Murine) MBD6 Antibodies:
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Frameshift mutations of MBD6 gene is associated with stomach and colorectal cancers.
We studied and showed that both MBD5 (show MBD5 Antibodies) and MBD6 interact with the mammalian PR-DUB Polycomb (show CBX2 Antibodies) protein complex in a mutually exclusive manner, and that the MBD (show DPEP1 Antibodies) of MBD5 (show MBD5 Antibodies) and MBD6 is both necessary and sufficient to mediate this interaction.
This study demonstrates examples of autistic patients carrying alterations in MBD6.
MBD6 is regulated by Ago2 (show EIF2C2 Antibodies) via an interaction with Oct4 (show POU5F1 Antibodies), which alters self-renewal and gene expression in human adipose tissue-derived stem cells.
MBD5 (show MBD5 Antibodies) and MBD6 are unlikely to be methyl-binding (show MARCKS Antibodies) proteins, yet they may contribute to the formation or function of heterochromatin.
Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
methyl-CpG binding domain protein 6
, methyl-CpG-binding domain protein 6
, methyl-CpG-binding protein MBD6