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the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma.
Data indicate that MCM-BP binds USP7 (show USP7 Proteins) on chromatin and can mediate an interaction between the USP7 (show USP7 Proteins) and MCM proteins.
results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex
MCM-BP can decrease phosphorylation by DDK but is not a substrate.
MCM-BP silencing in human cells also delays MCM dissociation in l (show MCM7 Proteins)ate S phase
MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 (show MCM3 Proteins) to MCM7 (show MCM7 Proteins), which excluded MCM2 (show MCM2 Proteins).
Xenopus egg extracts, MCM-BP exists in a stable complex with MCM7 (show MCM7 Proteins), but is not associated with the MCM2-7 (show MCM2 Proteins) hexameric complex
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.
, mini-chromosome maintenance complex-binding protein
, minichromosome maintenance complex-binding protein