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anti-Rat (Rattus) MTA3 Antibodies:
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Human Polyclonal MTA3 Primary Antibody for ICC, IF - ABIN250687
Zhang, Stephens, Kumar: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 5 Pubmed References
As a master regulator, MTA3 governs the target selection for nucleosome remodeling and histone deacetylation and functions as a transcriptional repressor. MTA3 dysregulation is associated with tumor progression, invasion, and metastasis in various cancers. MTA (show DNMT1 Antibodies) is also a key regulator of E-cadherin (show CDH1 Antibodies) expression and epithelial-to-mesenchymal transition.
MTA3 depletion induced cell cycle arrest at the G1/S boundary. Western blotting analysis revealed that the knockdown of MTA3 decreased the protein levels of cyclin A (show CCNA2 Antibodies), cyclin D1 (show CCND1 Antibodies) and p-Rb. These results indicate that MTA3 plays an important role in NSCLC progression
Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer
Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers.
MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX (show BAX Antibodies), PARP (show COL11A2 Antibodies) expression.
This review focuses on the current knowledge about the function and regulation of MTA1 (show MTA1 Antibodies) and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival.
Using western blotting and luciferase assays, MTA3 was identified as a target of miR (show MLXIP Antibodies)-495
MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma.
Down-regulation of MTA3 and up-regulation of CGB5 (show CGB Antibodies) and Snail (show SNAI1 Antibodies) are associated with preeclampsia.
data are the first to disclose the presence and functional role of MTA3 in the testis, where its expression is regulated by developmental, metabolic, and hormonal cues and is closely associated with steroidogenic dysfunction. The
Bcl6 (show BCL6 Antibodies) middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Metastasis-associated protein 3 (show HSPB3 Antibodies) (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
These results demonstrate the importance of FOG-2 (show ZFPM2 Antibodies)/MTA (show DNMT1 Antibodies)/RbAp interactions for FOG-2 (show ZFPM2 Antibodies)-mediated transcriptional repression and further define the molecular interactions between the FOG (show APAF1 Antibodies) repression motif and the NuRD complex.
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity).
metastasis associated 1 family, member 3
, metastasis associated 3
, metastasis-associated protein MTA3-like
, metastasis associated family, member 3
, metastasis associated gene family, member 3
, metastasis-associated protein MTA3