Browse our anti-MYSM1 (MYSM1) Antibodies

Full name:
anti-Myb-Like, SWIRM and MPN Domains 1 Antibodies (MYSM1)
On www.antibodies-online.com are 64 Myb-Like, SWIRM and MPN Domains 1 (MYSM1) Antibodies from 14 different suppliers available. Additionally we are shipping MYSM1 Kits (4) and MYSM1 Proteins (4) and many more products for this protein. A total of 75 MYSM1 products are currently listed.
Synonyms:
2A-DUB, 2adub, C130067A03Rik, C530050H10Rik, RGD1311787, RP4-592A1.1
list all antibodies Gene Name GeneID UniProt
MYSM1 114803 Q5VVJ2
MYSM1 320713 Q69Z66
MYSM1 298247  

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anti-Human MYSM1 Antibodies:

anti-Mouse (Murine) MYSM1 Antibodies:

anti-Rat (Rattus) MYSM1 Antibodies:

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Top referenced anti-MYSM1 Antibodies

  1. Human Polyclonal MYSM1 Primary Antibody for EIA, FACS - ABIN953592 : Zhu, Zhou, Wang, Puc, Ohgi, Erdjument-Bromage, Tempst, Glass, Rosenfeld: A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. in Molecular cell 2007 (PubMed)
    Show all 4 references for 953592

  2. Human Polyclonal MYSM1 Primary Antibody for IHC, ELISA - ABIN1535215 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 2 references for 1535215

More Antibodies against MYSM1 Interaction Partners

Human Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. data suggested that expression of MYSM1 was associated with the progression of CRC (show CALR Antibodies) and might be a potential biomarker for clinical prognosis

  2. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation

  3. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings

  4. The SWIRM structure of human MYb (show MYB Antibodies)-like, Swirm and Mpn domain-containing protein (show MPND Antibodies)-1 (MYSM1), is reported.

  5. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported.

Mouse (Murine) Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. Mysm1 enhanced function of the IRF2 and IRF8 promoters, suggesting that Mysm1 governs the IRFs for hematopoietic stem cell homeostasis.

  2. MYSM1 activity at the prepro-B cell stage of development is important for the normal programming of B cell responses to stimulation once they complete their maturation process.

  3. Overall we conclude that Mysm1 expression within the niche is not essential for the maintenance of hematopoietic homeostasis.

  4. this study shows that MYSM1 is involved in the maintenance, activation and survival of CD8 (show CD8A Antibodies)+ T cells

  5. The results demonstrate that MYSM1 plays a critical role in Mesenchymal Stromal Cell maintenance and differentiation. This study also underscores the biological significance of deubiquitinase activity in Mesenchymal Stromal Cell function.

  6. MYSM1 is a critical negative regulator of p53 (show TP53 Antibodies) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (show BBC3 Antibodies) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function

  7. this study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation and antibody production, in addition to its opposing, active role in B cell development.

  8. MYSM1 is essential for normal HSC (show FUT1 Antibodies) function and progression of hematopoiesis in the fetal liver and HSC (show FUT1 Antibodies) maintenance in adult bone marrow.

  9. 2 motifs in MYSM1 are essential for innate immune suppression: the SWIRM domain that interacts with TRAF3 (show TRAF3 Antibodies) and TRAF6 (show TRAF6 Antibodies) and the metalloproteinase domain that removed K63 polyubiquitins. MYSM1 is a key negative regulator of the innate immune system

  10. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 (show TP53 Antibodies) activation.

MYSM1 Antigen Profile

Antigen Summary

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).

Alternative names and synonyms associated with MYSM1

  • Myb-like, SWIRM and MPN domains 1 (MYSM1) antibody
  • myb-like, SWIRM and MPN domains 1 (Mysm1) antibody
  • myb-like, SWIRM and MPN domains 1 (MYSM1) antibody
  • myb-like, SWIRM and MPN domains 1 (mysm1) antibody
  • 2A-DUB antibody
  • 2adub antibody
  • C130067A03Rik antibody
  • C530050H10Rik antibody
  • RGD1311787 antibody
  • RP4-592A1.1 antibody

Protein level used designations for MYSM1

histone H2A deubiquitinase MYSM1 , myb-like, SWIRM and MPN domain-containing protein 1 , 2A-DUB , Myb-like, SWIRM and MPN domain-containing protein 1

GENE ID SPECIES
114803 Homo sapiens
320713 Mus musculus
298247 Rattus norvegicus
424671 Gallus gallus
779416 Xenopus laevis
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