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Browse our MYSM1 (MYSM1) ELISA Kits

Full name:
Myb-Like, SWIRM and MPN Domains 1 ELISA Kits (MYSM1)
On www.antibodies-online.com are 4 Myb-Like, SWIRM and MPN Domains 1 (MYSM1) ELISA Kits from 2 different suppliers available. Additionally we are shipping MYSM1 Antibodies (65) and MYSM1 Proteins (4) and many more products for this protein. A total of 76 MYSM1 products are currently listed.
Synonyms:
2A-DUB, 2adub, C130067A03Rik, C530050H10Rik, RGD1311787, RP4-592A1.1
list all ELISA KIts Gene Name GeneID UniProt
MYSM1 114803 Q5VVJ2
MYSM1 320713 Q69Z66
Rat MYSM1 MYSM1 298247  

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MYSM1 (MYSM1) ELISA Kits by Reactivity

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Human Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation

  2. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings

  3. The SWIRM structure of human MYb (show MYB ELISA Kits)-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported.

  4. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported.

Mouse (Murine) Myb-Like, SWIRM and MPN Domains 1 (MYSM1) interaction partners

  1. The results demonstrate that MYSM1 plays a critical role in Mesenchymal Stromal Cell maintenance and differentiation. This study also underscores the biological significance of deubiquitinase activity in Mesenchymal Stromal Cell function.

  2. MYSM1 is a critical negative regulator of p53 (show TP53 ELISA Kits) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (show BBC3 ELISA Kits) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function

  3. this study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation and antibody production, in addition to its opposing, active role in B cell development.

  4. MYSM1 is essential for normal HSC (show FUT1 ELISA Kits) function and progression of hematopoiesis in the fetal liver and HSC (show FUT1 ELISA Kits) maintenance in adult bone marrow.

  5. 2 motifs in MYSM1 are essential for innate immune suppression: the SWIRM domain that interacts with TRAF3 (show TRAF3 ELISA Kits) and TRAF6 (show TRAF6 ELISA Kits) and the metalloproteinase domain that removed K63 polyubiquitins. MYSM1 is a key negative regulator of the innate immune system

  6. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 (show TP53 ELISA Kits) activation.

  7. Data indicate that histone H2A deubiquitinase Mysm1 is required for dendritic cell development.

  8. Mysm1-mediated epigenetic regulation has a role in controlling hematopoietic stem cell maintenance, self-renewal, and differentiation

  9. MYSM1 is required for natural killer cell maturation, including the the recruitment of nuclear factor Il-3 to the ID2 locus.

  10. Data indicate a role for histone H2A-deubiquitinase Mysm1 in the maintenance of bone marrow stem cell function, in the control of oxidative stress and genetic stability in hematopoietic progenitors.

MYSM1 Antigen Profile

Antigen Summary

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).

Alternative names and synonyms associated with MYSM1

  • Myb-like, SWIRM and MPN domains 1 (MYSM1) Elisa Kit
  • myb-like, SWIRM and MPN domains 1 (Mysm1) Elisa Kit
  • myb-like, SWIRM and MPN domains 1 (MYSM1) Elisa Kit
  • myb-like, SWIRM and MPN domains 1 (mysm1) Elisa Kit
  • 2A-DUB Elisa Kit
  • 2adub Elisa Kit
  • C130067A03Rik Elisa Kit
  • C530050H10Rik Elisa Kit
  • RGD1311787 Elisa Kit
  • RP4-592A1.1 Elisa Kit

Protein level used designations for MYSM1

histone H2A deubiquitinase MYSM1 , myb-like, SWIRM and MPN domain-containing protein 1 , 2A-DUB , Myb-like, SWIRM and MPN domain-containing protein 1

GENE ID SPECIES
114803 Homo sapiens
320713 Mus musculus
298247 Rattus norvegicus
424671 Gallus gallus
779416 Xenopus laevis
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