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Suggest a novel role of PCGF2 in arsenic trioxide-mediated degradation of PML (show PML Proteins)-RARA (show RARA Proteins) that PCGF2 might act as a negative regulator of UBE2I (show UBE2I Proteins) via direct interaction.
Mel-18 underexpression in luminal breast cancer cells caused ER-alpha (show ESR1 Proteins) downregulation.Its overexpression restored it in triple-negative breast cancer cells. MEL-18 suppressed SUMOylation of the ESR1 (show ESR1 Proteins) transactivators p53 (show TP53 Proteins) and SP1 (show PSG1 Proteins).
It was therefore concluded that the lower Mel-18 expression might contribute to colorectal cancer development/progression.
Mel-18 functions as a tumor suppressor by its novel negative control of the epithelial-mesenchymal transition in breast cancer.
Findings suggest that Mel-18 is a novel negative regulator of breast cancer stem cell (CSC) that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt (show WNT2 Proteins)-mediated Notch (show NOTCH1 Proteins) signaling.
PCGF2, a PRC1 (show PRC1 Proteins) gene, played a negative role in the granulocytic differentiation of human APL (show FASL Proteins) cells.
these findings provide that Mel-18 is a novel regulator of tumor angiogenesis through regulating HIF-1alpha (show HIF1A Proteins) and its target VEGF (show VEGFA Proteins) expressions mediated by the PTEN/PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway, suggesting a new tumor-suppressive role of Mel-18 in human breast cancer.
Loss of Mel-18 is associated with prostate cancer.
Our analysis showed correlation between BMI1 (show BMI1 Proteins) and PCGF2 gene's expression and survival in children with medulloblastoma.
Bmi-1 (show BMI1 Proteins)/Mel-18 ratio can be potentially used as a tool for stratifying women at risk of developing breast malignancy.
Data indicate that Bmi1 (show BMI1 Proteins) and Mel18 have opposing functions and are present in distinct complexes.
Mel-18 controls the enrichment of tumor-initiating cells in side population fraction in mouse mammary gland cancer.
Data show that Mel-18 and Ezh2 (show EZH2 Proteins) positively regulate the expression of Il17a (show IL17A Proteins) and Il17f (show IL17F Proteins).
Chemokine (show CCL1 Proteins)-mediated thymopoiesis is regulated by a mammalian Polycomb (show CBX2 Proteins) group gene, mel-18
the stoichiometry and/or equilibrium of subunits of the class II Polycomb complex containing Mel-18 might be regulated by changes in phosphorylation status via the PKC signaling pathway
Results provide genetic evidence that Cited2 controls the expression of INK4a/ARF and fibroblast proliferation, at least in part via the polycomb-group genes Bmi1 and Mel18.
Loss or knockdown of mel-18 leads to the expression of Hoxb4 (show HOXB4 Proteins), an increase in the proportion of hematopoietic stem cells in G0 phase, and the subsequent promotion of HSC (show FUT1 Proteins) self-renewal.
Mel-18 contributes to the maintenance of the active state of the Hes-1 gene as a cellular memory system, thereby supporting the expansion of early T lymphocyte progenitors.
Sf3b1 (show SF3B1 Proteins)-Zfp144 protein interaction is essential for true Polycomb (show CBX2 Proteins) group proteins mediated repression of Hox (show MSH2 Proteins) genes.
observed that expression of the PcG genes-bmi1 (show BMI1 Proteins) and mel-18-is correlated with self-renewal and differentiation of HSCs. Thus, it was suggested that the balance between Bmi1 (show BMI1 Proteins) and Mel-18 regulates self-renewal of HSCs
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
polycomb group RING finger protein 2
, zinc finger protein 144 (Mel-18) (human homolog)
, polycomb group ring finger 2
, ring finger protein 110
, DNA-binding protein Mel-18
, zinc finger protein 144
, melanoma nuclear protein 18