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KDM5A (show KDM5A ELISA Kits)-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 (show BMP2 ELISA Kits) in osteoporotic conditions.
Kdm5a (show KDM5A ELISA Kits) associates with p50 (show LSP1 ELISA Kits) and binds to the Socs1 (show SOCS1 ELISA Kits) promoter region in resting natural killer cells.
The present study was designed to detect the expression of Histone H3 (show HIST3H3 ELISA Kits) lysine 4 methylation and its demethylases LSD1 (show KDM1A ELISA Kits), RBP2 and SMCX (show KDM5C ELISA Kits) in 21-, 40- and 60-day-old mouse testes.
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C (show EHMT2 ELISA Kits) and the H3K4 demethylase (show MBD2 ELISA Kits) Jarid1a/KDM5A (show KDM5A ELISA Kits).
In terminally differentiated cells, common KDM5A and E2F4 gene targets were bound by the pRB-related protein p130, a DREAM complex component.
genetic ablation of Rbp2 decreases tumor formation and prolongs survival in Rb1(+/-) mice and Men1-defective mice.
Study reports that RBP2 is a demethylase (show MBD2 ELISA Kits) that specifically catalyzes demethylation on histone H3 (show HIST3H3 ELISA Kits) lysine 4, whose methylation is normally associated with transcriptionally active genes.
JARID1a (show KDM5A ELISA Kits) formed a complex with CLOCK-BMAL1 (show ARNTL ELISA Kits) which was recruited to Per2 (show PER2 ELISA Kits) promoter;it increased histone acetylation by inhibiting histone deacetylase 1 (show HDAC1 ELISA Kits) function and enhanced transcription by CLOCK-BMAL1 (show ARNTL ELISA Kits); JARID1a (show KDM5A ELISA Kits) depletion shortened period of circadian rhythms
KDM5A (show KDM5A ELISA Kits) interacts physically with RBP-J (show RBPJ ELISA Kits)
RBP2 knockout mice have a higher rate of neonatal mortality and expression of CRBPII in the placenta
Domain-swapped dimers of RBP2 (show KDM5A ELISA Kits) provides evidence for ordered folding intermediates.
promotes overexpression and activation of BCL2 (show BCL2 ELISA Kits) in acute lymphoblastic leukemia development and progression
RBP2 (show KDM5A ELISA Kits) could induce epithelial-mesenchymal transition in esophageal cancer cells and exert a greater effect on the expression of E-cadherin (show CDH1 ELISA Kits) in lung squamous cells than in esophageal squamous cells.
RBP2 (show KDM5A ELISA Kits) promotes HIF-1alpha (show HIF1A ELISA Kits)-VEGF (show VEGFA ELISA Kits)-induced angiogenesis of non-small cell lung cancer via the Akt (show AKT1 ELISA Kits) pathway.
The structure of retinal-bound human CRBPII and the structure of retinol-bound CRBPII with retinol fully occupying the binding pocket are reported.
Data show that CRBPI (show RBP1 ELISA Kits) and CRBPII bind 9-cis-retinol and 9-cis-retinal with high affinities, albeit with affinities somewhat lower than for all-trans-retinol and all-trans-retinal.
retinoic acid responsiveness of the human CRBP II promoter is mediated by an indirect mechanism and that this mechanism is associated with enterocyte differentiation.
We report here the X-ray structures of human apo (show C9orf3 ELISA Kits) and holo CRBP II solved at 1.2 A resolution and compare the two structures between them and with the structures of zebrafish and rat CRBP II.
HNF-4alpha (show HNF4A ELISA Kits) is an important transcriptional factor that regulates human CRBPII gene expression; possibility for a novel function of HNF-4alpha (show HNF4A ELISA Kits) in the regulation of human intestinal vitamin A absorption and metabolism
RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle.
retinol-binding protein 2
, retinol binding protein 2, cellular
, histone demethylase JARID1A
, jumonji, AT rich interactive domain 1A (Rbp2 like)
, jumonji/ARID domain-containing protein 1A
, lysine-specific demethylase 5A
, retinoblastoma binding protein 2
, retinoblastoma-binding protein 2
, cellular retinol-binding protein II
, retinol-binding protein 2, cellular
, Retinol-binding protein 2 cellular
, Retinol-binding protein 2, cellular