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Ectopic expression of Rcor2 in both mouse and human somatic cells effectively substituted the requirement for exogenous Sox2 expression in somatic cell reprogramming.
Rcor2, a co-repressor of LSD1 (show KDM1A ELISA Kits), controls neurogenesis in the developing mouse brain.
p120-catenin (show CTNND1 ELISA Kits) regulates REST and CoREST and modulates mouse embryonic stem cell differentiation.
miR (show MLXIP ELISA Kits)-22 and miR (show MLXIP ELISA Kits)-124 are expressed in the cortical wall where they target components of the CoREST/REST transcriptional repressor complex, thereby regulating doublecortin (show DCX ELISA Kits) transcription in migrating neurons.
The results of this study suggested that Rcor2 downregulation in astrocytes induces inflammation.
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 ELISA Kits) and a sharp decline in Rcor1 levels counteract LSD1 (show KDM1A ELISA Kits)/Rcor1/2-mediated differentiation.
Knockdown of kdm1a (show KDM1A ELISA Kits) or its partner REST corepressor 2 (rcor2) in 3T3-L1 preadipocytes results in increased expression of inflammatory cytokines and chemokines by these cells.
The loss of CoREST function perturbs the dynamics of neuronal precursor cell populations, transiently increasing the fraction of cells remaining in progenitor states.
Our data uncover a mechanism of regulation of the LSD1 (show KDM1A ELISA Kits)-CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf (show HMG20A ELISA Kits) in neuronal differentiation.
ES cells specific Rcor2-LSD1 complex not Rcor1-LSD1 complex regulates ESC property.
In neural stem cells, identified a larger number of CoREST (1,820) compared with REST (322) target genes. The majority of these CoREST targets do not contain known RE1 (show NPC2 ELISA Kits) motifs.
These data reveal a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation.
May act as a component of a corepressor complex that represses transcription (Potential).
REST corepressor 2
, REST corepressor 2-like
, RE1-silencing transcription factor (REST) co-repressor 1
, REST co-repressor 2
, co-repressor of Rest
, RE1-silencing transcription factor (REST) co-repressor 2