Browse our RECQL4 Proteins (RECQL4)

On www.antibodies-online.com are 3 RecQ Protein-Like 4 (RECQL4) Proteins from 2 different suppliers available. Additionally we are shipping RECQL4 Antibodies (37) and many more products for this protein. A total of 45 RECQL4 products are currently listed.
Synonyms:
MGC145453, RECQ4, RTS, xrecq4
list all proteins Gene Name GeneID UniProt
Rat RECQL4 RECQL4 300057  
RECQL4 9401 O94761
RECQL4 79456 Q75NR7

RECQL4 Proteins (RECQL4) by Origin

More Proteins for RECQL4 Interaction Partners

Xenopus laevis RecQ Protein-Like 4 (RECQL4) interaction partners

  1. RecQ4 plays an important role in the conversion of pre-initiation complexes into active replisomes requiring the unwinding of origin DNA in vertebrates.

  2. RecQL4 is loaded adjacent to Ku heterodimer-binding sites on damaged chromatin, and functions in the repair of double-stranded DNA breaks.

  3. RecQ4 performs an essential role in the assembly of replication machinery through interaction with Cut5 (show TOPBP1 Proteins) in vertebrates.

Human RecQ Protein-Like 4 (RECQL4) interaction partners

  1. These results solidify Hrq1 as a true RecQ4 homolog and position it as the premier model to determine how RecQ4 mutations lead to genomic instability and disease.

  2. High RECQL4 expression is associated with Cisplatin Resistance in Gastric Cancer.

  3. Mutations in RECQL4 are responsible for the majority of cases of Rothmund-Thomson syndrome . RECQL4 is important not only in Cancer development but also in the aging process.

  4. High RecQL4 expression is associated with osteosarcoma.

  5. this study demonstrates for the first time that, owing to its mitochondrial functions, the accessory mitochondrial replication helicase RECQL4 prevents the invasive step in the neoplastic transformation process.

  6. These results reveal novel possible roles of RecQ4 in DNA replication and genome stability.

  7. RECQL4 is tumour promoting in established breast cancers

  8. RecQL4-dependent association of Mcm10 (show MCM10 Proteins) and Ctf4 (show WDHD1 Proteins) with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.

  9. No RECQL4 mutations were found in the BGS group without poikiloderma, confirming that RECQL4 sequencing was not indicated in this phenotype.

  10. This finding provided the key to unravel the correlation between the RECQL4 genotype and the mild phenotype of the two siblings of Rothmund-Thomson Syndrome.

Mouse (Murine) RecQ Protein-Like 4 (RECQL4) interaction partners

  1. RECQL4 is essential for normal bone development. Animals with no Recql4 in bone cells did not develop osteosarcoma.

  2. findings show that RECQL4 is critical for skeletal development by modulating p53 (show TP53 Proteins) activity in vivo.

  3. data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases

  4. dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to Rothmund-Thomson syndrome features in mice.

  5. Elevated expression of RECQL4 accompanies progression of the Rothmund-Thomson Syndrome into osteosarcoma in humans and mice.

  6. Recql4-deficient mice show growth retardation and skin abnormalities.

  7. Recql4 functions as a regulatory protein during osteoprogenitor proliferation, a critical cellular event during skeleton development.

  8. we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14 (show LRRC14 Proteins); a novel member of the LRR gene family, on the opposite strand

RECQL4 Protein Profile

Protein Summary

The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes.

Alternative names and synonyms associated with RECQL4

  • RecQ protein-like 4 (Recql4)
  • RecQ protein-like 4 (RECQL4)
  • RecQ protein-like 4 (recql4)
  • MGC145453 protein
  • RECQ4 protein
  • RTS protein
  • xrecq4 protein

Protein level used designations for RecQ Protein-Like 4 Proteins (RECQL4)

ATP-dependent DNA helicase Q4 , RecQ protein-like 4 , ATP-dependent DNA helicase Q4-like , DNA helicase, RecQ-like type 4 , DNA helicase, RecQ-like, type 4 , RecQ helicase protein-like 4

GENE ID SPECIES
300057 Rattus norvegicus
429982 Gallus gallus
464469 Pan troglodytes
482101 Canis lupus familiaris
515472 Bos taurus
703354 Macaca mulatta
734225 Xenopus laevis
780344 Xenopus (Silurana) tropicalis
100399025 Callithrix jacchus
100456857 Pongo abelii
100477071 Ailuropoda melanoleuca
100064627 Equus caballus
9401 Homo sapiens
79456 Mus musculus
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