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This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 (show BMP2 Proteins) account for about 7% of infants with midline forms of craniosynostosis.
Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (show UBE2O Proteins) and SMAD6 cooperated in the regulation of BMP7 (show BMP7 Proteins)-induced adipogenesis
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Loss of SMAD6 is associated with lung adenocarcinoma.
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
results suggest that MyD88 (show MYD88 Proteins) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (show TGFB1 Proteins)-mediated negative regulation of MyD88 (show MYD88 Proteins)-dependent pro-inflammatory signalling
Data show that Runx1 (show RUNX1 Proteins), in conjunction with Fli1 (show FLI1 Proteins), Gata2 (show GATA2 Proteins), and Scl (show KRT7 Proteins), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
Smad6 and Smad7, inhibitors of BMP signaling, were up-regulated in HFE-mutant hereditary hemochromatosis compared to controls, disruptin bone morphogenic protein signaling.
A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (show NKX2-5 Proteins)).
These results indicate that PRIP (show NCOA6 Proteins) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (show SMAD1 Proteins) phosphorylation, through the methylation of inhibitory Smad6
These findings suggest that TNF-alpha (show TNF Proteins) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (show BMP2 Proteins) signaling inhibitor, Smad6.
The Smad6 is a novel target of Arkadia (show RNF111 Proteins), and that Arkadia (show RNF111 Proteins) positively regulates BMP signalling via degradation of Smad6, Smad7 (show SMAD7 Proteins) and c-Ski (show SKI Proteins)/SnoN (show SKIL Proteins).
Smad6 inhibits non-canonical TGF-beta1 (show TGFB1 Proteins) signaling by recruiting the deubiquitinase A20 (show TNFAIP3 Proteins) to TRAF6 (show TRAF6 Proteins).
Hepcidin (show HAMP Proteins), Smad6 and Smad7 (show SMAD7 Proteins) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (show SMAD1 Proteins) signaling pathway.
Sema7A (show SEMA7A Proteins) positively regulates the production of transforming growth factor (TGF)-beta1 (show TGFB1 Proteins) and Smad6 to facilitate West Nile virus pathogenesis in mice.
Results indicate that peptidyl-prolyl isomerase Pin1 (show PIN1 Proteins) Associates with Smad3 (show SMAD3 Proteins) and Smad6.
Data show that Runx1 (show RUNX1 Proteins), in conjunction with Fli1 (show FLI1 Proteins), Gata2 (show GATA2 Proteins), and Scl (show TAL1 Proteins), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD, mothers against DPP homolog 6
, MAD homolog 6
, Mothers against decapentaplegic, drosophila, homolog of, 6
, SMAD 6
, mothers against DPP homolog 6
, mothers against decapentaplegic homolog 6
, Smad 6
, mad homolog 7
, MAD, mothers against decapentaplegic homolog 6