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anti-Human SMARCA5 Antibodies:
anti-Mouse (Murine) SMARCA5 Antibodies:
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Human Polyclonal SMARCA5 Primary Antibody for IP, WB - ABIN188620
Bryant, Colgrove, Knipe: Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication. in mBio 2011
Show all 4 Pubmed References
Human Monoclonal SMARCA5 Primary Antibody for ChIP, ICC - ABIN2668296
Sims, Millhouse, Chen, Lewis, Erdjument-Bromage, Tempst, Manley, Reinberg: Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. in Molecular cell 2007
Show all 3 Pubmed References
Human Polyclonal SMARCA5 Primary Antibody for IF, WB - ABIN521924
Wang, Castro, Mulder, Markowetz: Posterior association networks and functional modules inferred from rich phenotypes of gene perturbations. in PLoS computational biology 2012
Human Polyclonal SMARCA5 Primary Antibody for ICC, IF - ABIN4354728
Polyakova, Borman, Grimley, Vamathevan, Hayes, Solari: Identification of novel interacting partners of Sirtuin6. in PLoS ONE 2012
CNBP (show CNBP Antibodies) up-regulates tbx2b and smarca5, and down-regulates wnt5b (show WNT5B Antibodies) gene expression.
The tight coupling of ATP hydrolysis to DNA translocation suggests that DNA translocation is not energetically rate limiting for nucleosome repositioning by ISWI.
results demonstrate that distinctly from its role in spindle assembly, RanGTP maintains spindle microtubules in anaphase through the local activation of ISWI and that this is essential for proper chromosome segregation
Plays a critical role for ISWI chromatin remodeling complexes in neural development, including eye differentiation, in the Xenopus laevis embryo.
present the X-ray structure of Xenopus laevis ISWI SANT domain, derived from limited proteolysis of a C-terminal fragment of ISWI protein
A model has been proposed in which a base excision repair complex containing damaged chromatin is recruited to specific locations in the nuclear matrix for repair, with this recruitment mediated by XRCC1 (show XRCC1 Antibodies)-SNF2H interaction.
Overexpression of hSNF2H is associated with glioma.
The action of SNF2H at CTCF (show CTCF Antibodies) sites is functionally important as depletion of CTCF (show CTCF Antibodies) or SNF2H affects transcription of a common group of genes.
Knockdown of SMARCA5 expression in MDA-MB-231 and MDA-MB-435s cell lines.
Data show the mechanism of nucleosome sliding by the chromatin remodeling motor SNF2h protein.
CHD3.1 and ACF1 (show BAZ1A Antibodies)-SNF2H display counteractive activities but similar histone affinities.
Data show that CCCTC-binding factor (CTCF (show CTCF Antibodies)) together with ISWI (show SMARCA1 Antibodies) ATPase (show DNAH8 Antibodies) SMARCA5 and members of the Cohesin complex (show SMC3 Antibodies) associate with the SPI1 (show SPI1 Antibodies) protein is disrupted in acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) blasts.
SMARCA5 targeting to UV-C damage depends on transcription and histone modifications and requires functional SWI2/SNF2 (show SMARCA2 Antibodies)-ATPase (show DNAH8 Antibodies) and SLIDE domains.
this study finds that the H4 tail promotes ATP-binding pocket closure in SNF2h.
study unveils a functional link between DNA damage-induced poly(ADP-ribosyl)ation, SMARCA5-mediated chromatin remodeling and RNF168 (show RNF168 Antibodies)-dependent signaling and repair of DSBs.
VGF (show VGF Antibodies) neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF (show VGF Antibodies)-encoding adenoviruses removed the requirement of exercise for survival.
Snf2h is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation.
Snf2h controls chromatin organization and histone H1 (show H1F0 Antibodies) dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation.
The results demonstrated a novel role of CECR2 (show CECR2 Antibodies)-containing complexes in spermatogenesis and showed that CECR2 (show CECR2 Antibodies) interacts predominantly with SNF2H instead of SNF2L (show SMARCA1 Antibodies) in the testis.
role for SNF2H in both repression and activation of cytokine genes.
Smarca5 is a key regulator of global chromatin structure.
Smarca5-NoRC complex has a role in heterochromatin formation and silencing of ribosomal gene transcription
Snf2h-/- embryos die during the periimplantation stage. Blastocyst outgrowth experiments indicate that loss of Snf2h results in growth arrest and cell death of both the trophectoderm and inner cell mass.
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
, actin dependent regulator of chromatin A5
, matrix associated
, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
, imitation switch ISWI
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a5
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
, sucrose nonfermenting protein 2 homolog
, sucrose nonfermenting-like 5