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BAF57, BAF60a (show SMARCD1 Proteins) and SNF5 (show SMARCB1 Proteins) might act as novel pro-senescence factors in both normal and tumor human skin cells
We report here three additional individuals with clinical features consistent with CSS (show CMAS Proteins) and alterations in SMARCE1, one of which is novel. The probands all exhibited dysmorphic facial features, moderate developmental and cognitive delay, poor growth, and hypoplastic digital nails/phalanges, including digits not typically affected in the other genes associated with CSS (show CMAS Proteins).
SMARCE1 mutational hits, including novel SMARCE1 mutations, were found in six of eight tested patients with clear cell meningioma
SMARCE1 plays an essential role in breast cancer metastasis by protecting cells against anoikis through the HIF1A (show HIF1A Proteins)/PTK2 (show PTK2 Proteins) pathway.
An exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations. [review]
a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation.
Addition of the EGFR (show EGFR Proteins) inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR (show EGFR Proteins) oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors.
The results suggested that BAF57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that BAF57 may be a target for ovarian cancer therapy.
BAF (show BANF1 Proteins) complex gene SMARCE1 is mutated in Coffin-Siris syndrome patients.
Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SmarCE1 gene.
The N terminus of Brdt (show BRDT Proteins) is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.
suggest a novel mechanism for transcriptional repression by TSHZ3 (show ZNF537 Proteins) in which TSHZ3 (show ZNF537 Proteins) and BAF57 cooperate to modulate MyoD (show MYOD1 Proteins) activity on the Myog (show MYOG Proteins) promoter to regulate skeletal muscle differentiation.
Data show that neuregulin-1 (show NRG1 Proteins) (NRG) inhibition is followed by a decrease in NSC proliferation and of neuronal or oligodendroglial differentiation, and that Nrg-1 (show NRG1 Proteins) physically interacts with BRM (show SMARCA2 Proteins) and BAF57.
Reciprocal regulation of CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) expression by SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins)-like BAF (show BANF1 Proteins) complexes.
The ER interacts with BAF57, which is stimulated by estrogen and requires both a functional hormone-binding domain & the DNA-binding region of the ER. The p160 (show MSH6 Proteins) family of coactivators interacts with BAF57. Their potentiation of transcription depends on it.
Smarce1 (Baf27)is a critical modulator of the androgen neceptor (AR) that is capable of altering AR activity, coactivator function, and AR-dependent proliferation.
BAF (show BANF1 Proteins) complex uses BAF57 to remodel the endogenous, H1-containing chromatin at the CD4 (show CD4 Proteins) silencer, which facilitates the binding of Runx1 (show RUNX1 Proteins), a key repressor of CD4 (show CD4 Proteins) transcription.
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
, BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
, chromatin remodeling complex BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1