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ADA2a and ADA2b, two human homologues of yeast Ada2, each have the ability to form a heterotrimer with ADA3 and GCN5L but that only the ADA2b homologue is found in STAGA.
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003
transcriptional adaptor 2 (ADA2 homolog, yeast)-beta
, transcriptional adaptor 2B
, transcriptional adapter 2-beta
, ADA2-like protein beta