Browse our TFAM Proteins (TFAM)

Full name:
Transcription Factor A, Mitochondrial Proteins (TFAM)
On are 12 Transcription Factor A, Mitochondrial (TFAM) Proteins from 5 different suppliers available. Additionally we are shipping TFAM Antibodies (141) and TFAM Kits (10) and many more products for this protein. A total of 176 TFAM products are currently listed.
AI661103, Hmgts, MGC153358, MTTF1, Mttfa, mttfa-A, TCF6, TCF6L1, TCF6L2, TCF6L3, tsHMG, xl-mtTFA, zgc:153358
list all proteins Gene Name GeneID UniProt
TFAM 7019 Q00059
TFAM 21780 P40630
TFAM 83474 Q91ZW1

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TFAM Proteins (TFAM) by Origin

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Top referenced TFAM Proteins

  1. Human TFAM Protein expressed in Escherichia coli (E. coli) - ABIN667339 : Aquilano, Vigilanza, Baldelli, Pagliei, Rotilio, Ciriolo: Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. in The Journal of biological chemistry 2010 (PubMed)
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More Proteins for TFAM Interaction Partners

Human Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. In vivo, AICAR (show ATIC Proteins) significantly reduced osteosarcoma growth without apparent body weight loss and AICAR (show ATIC Proteins) increased both mitochondrial proliferation and apoptotic activity in treated tumor tissues. AICAR (show ATIC Proteins) showed anticancer effects in osteosarcoma cells through an AMPK (show PRKAA1 Proteins)-dependent peroxisome proliferatoractivated receptor-gamma coactivator-1alpha (PGC-1alpha)/mitochondrial transcription factor A (TFAM)/mitochondrial pathway

  2. the present study identified the interaction of miR (show MLXIP Proteins)-590-3p and TFAM in colon cancer. TFAM was identified as a target of miR (show MLXIP Proteins)-590-3p, and miR (show MLXIP Proteins)-590-3p enhanced the proliferation of SW480 cells.

  3. The results of the present study provided evidence that resistance to cisplatin chemotherapy in ERpositive breast cancer may be through TFAM and indicated that TFAM may be a target for chemoresistance in patients with breast cancer.

  4. miR (show MLXIP Proteins)-199a-3p is able to attenuate cisplatin resistance in breast cancer cells through inhibiting TFAM expression.

  5. We conducted a meta-analysis of studies involving CHAT, TFAM, and VR22 (show CTNNA3 Proteins) polymorphisms and Alzheimer disease susceptibility. For TFAM and VR22 (show CTNNA3 Proteins), no significant association was detected in studied single-nucleotide polymorphisms (SNPs).Rs1937 and rs2306604 of TFAM, are not significantly associated with AD risk.

  6. Results showed that TFAM formed oligomers in mitochondria by in situ chemical cross-linking and suggested the importance of the dimerization of TFAM molecules in the distribution of mtDNA in cells.

  7. Report failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers in skeletal muscle of chronic obstructive pulmonary disease patients.

  8. Data show that mtTFA proteins are highly expressed in cancer and drug-resistant cells compared to normal cells, and the mtTFA expression is upregulated by signals of oxidative and DNA damage stress in cancer cells. [review]

  9. TFAM overexpression suppressed mitoROS and their upregulation in rat cardiomyocytes.

  10. TFAM dimerization enhances mitochondrial DNA compaction by promoting looping of the DNA.

Pig (Porcine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.

Cow (Bovine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.

  2. de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (show NRF1 Proteins) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.

Mouse (Murine) Transcription Factor A, Mitochondrial (TFAM) interaction partners

  1. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis.

  2. During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.

  3. TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.

  4. Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.

  5. There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.

  6. This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.

  7. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (show TNF Proteins) release via RAGE (show AGER Proteins)- and TLR9 (show TLR9 Proteins)-responsive plasmacytoid dendritic cells.

  8. overexpression of TFAM can restore mitochondrial function to normal levels in NYGGF4 (show PID1 Proteins)-overexpressing adipocytes

  9. Acute exercise induces tumour suppressor protein p53 (show TP53 Proteins) translocation to the mitochondria and promotes a p53 (show TP53 Proteins)-Tfam-mitochondrial DNA complex in skeletal muscle.

  10. Data indicate that TFAM-deficient keratinocytes failed to generate mitochondria-derived reactive oxygen species, and prevented the transmission of Notch (show NOTCH1 Proteins) and beta-catenin (show CTNNB1 Proteins) signals for epidermal differentiation and hair follicle development.

TFAM Protein Profile

Protein Summary

This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TFAM

  • transcription factor A, mitochondrial (TFAM)
  • transcription factor A, mitochondrial (tfam)
  • transcription factor A, mitochondrial (Tfam)
  • AI661103 protein
  • Hmgts protein
  • MGC153358 protein
  • MTTF1 protein
  • Mttfa protein
  • mttfa-A protein
  • TCF6 protein
  • TCF6L1 protein
  • TCF6L2 protein
  • TCF6L3 protein
  • tsHMG protein
  • xl-mtTFA protein
  • zgc:153358 protein

Protein level used designations for TFAM

transcription factor A, mitochondrial , HMG box mitochondrial transcription factor , mitochondrial transcription factor 1 , mitochondrial transcription factor A , transcription factor 6 , transcription factor 6-like 1 , transcription factor 6-like 2 (mitochondrial transcription factor) , transcription factor 6-like 3 , mtTFA , transcription factor 6-like 2 , TS-HMG , testis-specific HMG-box protein m-tsHMG , testis-specific high mobility group protein

373888 Gallus gallus
394385 Xenopus laevis
571106 Danio rerio
7019 Homo sapiens
488989 Canis lupus familiaris
397279 Sus scrofa
510059 Bos taurus
21780 Mus musculus
83474 Rattus norvegicus
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