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anti-Human C1S antibody for Enzyme Immunoassay

Recommended C1S Antibody (supplied by: Log in to see )

Antigen
Complement Component 1, S Subcomponent (C1S) Antibodies
  • AA959438
  • AI255193
  • AI327365
  • C1S
  • C1sa
  • r-gsp
Reactivity
Human
69
19
19
2
1
Host
Mouse
43
23
3
Clonality
Monoclonal
Conjugate
This C1S antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
46
25
19
11
10
9
6
4
3
3
2
1
1
1
1
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Catalog No. ABIN1105612
$ 544.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088338397 ABIN1105613 Func EIA IHC (fro) IHC (p) IP WB Mouse IgG2a activated Log in to see M241 2
0.00088338397 ABIN614875 EIA IHC (p) Goat IgG Log in to see Polyclonal

Top referenced anti-C1S antibody for Enzyme Immunoassay

Similar anti-C1S Antibodies

Application / Reactivity Human
ELISA 25 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Flow Cytometry (FACS) 9 Antibodies
Functional Studies (Func) 2 Antibodies
Immunoassay (IA) 1 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunodiffusion (ID) 1 Antibodies
Immunofluorescence (IF) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 19 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 4 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 11 Antibodies
Immunoprecipitation (IP) 5 Antibodies
Inhibition Assay (InhA) 1 Antibodies
Western Blotting (WB) 47 Antibodies

General

Antigen Complement Component 1, S Subcomponent (C1S) Antibodies
Reactivity Human
(69), (19), (19), (2), (1)
Host Mouse
(43), (23), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This C1S antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(46), (25), (19), (11), (10), (9), (6), (4), (3), (3), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-C1S Antibody

Target Details C1S Application Details Handling References for anti-C1S Antibody (ABIN1105612) Images
Specificity Monoclonal antibody M81 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. It blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein G
Clone M81
Isotype IgG1

Target Details C1S

Product Details anti-C1S Antibody Application Details Handling References for anti-C1S Antibody (ABIN1105612) Images back to top
Antigen
Alternative Name C1s (C1S Antibody Abstract)
Background Activated C1s is a glycosylated single-polypeptide zymogen, MW 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a.Synonyms: C1 esterase, Complement 1s, Complement C1s, Complement C1s subcomponent, Complement component 1 subcomponent s
Gene ID 716
NCBI Accession NP_001725
UniProt P09871
Research Area Immunology, Innate Immunity, Complement Factors
Pathways Complement System

Application Details

Product Details anti-C1S Antibody Target Details C1S Handling References for anti-C1S Antibody (ABIN1105612) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-C1S Antibody Target Details C1S Application Details References for anti-C1S Antibody (ABIN1105612) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

References for anti-C1S Antibody (ABIN1105612)

Product Details anti-C1S Antibody Target Details C1S Application Details Handling Images back to top
Background publications

Nakagawa, Sakiyama, Tsuchida, Yamaguchi, Toyoguchi, Masuda, Moriya: "Complement C1s activation in degenerating articular cartilage of rheumatoid arthritis patients: immunohistochemical studies with an active form specific antibody." in: Annals of the rheumatic diseases, Vol. 58, Issue 3, pp. 175-81, 1999

Matsumoto, Nagaki, Kitamura, Kuramitsu, Nagasawa, Seya: "Probing the C4-binding site on C1s with monoclonal antibodies. Evidence for a C4/C4b-binding site on the gamma-domain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 8, pp. 2743-50, 1989