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Complement C5b-9 induce a JNK (show MAPK8 Proteins)/Bid (show BID Proteins)-dependent and JNK (show MAPK8 Proteins)-independent necrotic cell death.
The binding specificity between C8 beta and C8 alpha subunits is determined by a cooperative interaction of the N-terminal thrombospondin type 1 module and the membrane attack complex/perforin (show PRF1 Proteins) domain.
C8 alpha and C8 beta have correspondingly similar roles in MAC-mediated lysis of erythrocytes and bacterial killing. C8 gamma is not required for complement-mediated killing of Gram-negative bacteria.
Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 (show C13orf15 Proteins) dependent and this is in part through regulation of Akt (show AKT1 Proteins) and growth factor release.
C8 beta is one of the three subunits that comprise the component 8 (C8) of the complement system. C8 participates in the formation of Membrane Attack Complex that results in the lysis of cells. Patients with C8B deficiency are prone to bacteria infection.
complement component 8 subunit beta
, complement component C8 beta chain
, complement component C8 beta subunit
, complement component 8, beta subunit