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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||11 Antibodies||70 Antibodies|
|Flow Cytometry (FACS)||20 Antibodies||397 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies|
|Immunohistochemistry (IHC)||20 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||21 Antibodies|
|Immunoprecipitation (IP)||20 Antibodies|
|Western Blotting (WB)||29 Antibodies|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Functional Studies (Func)||31 Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This CD59 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-CD59 AntibodyTarget Details CD59 Application Details Handling Images
|Specificity||The antibody AM08314PU-N reacts with well defined epitope (around L33) on CD59 (Protectin), a 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissues. The MEM-43/5 does not compete with most other CD59 antibodies.|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|Characteristics||Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21,MACIF, MAC-IP, MIRL, HRF20, HRF-20, Membrane attack complex inhibition factor,Membrane inhibitor of reactive lysis, 20 kDa homologous restriction factor|
|Purification||Protein A Chromatography.|
|Immunogen||Thymocytes and T lymphocytes.|
Target Details CD59Product Details anti-CD59 Antibody Application Details Handling Images back to top
|Alternative Name||CD59 (CD59 Antibody Abstract)|
|Background||CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin|
|Research Area||Cardiovascular, Atherosclerosis, Hematopoietic Progenitors, Tyrosine Kinases, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD59 Antibody Target Details CD59 Handling Images back to top
Western Blot: 1-2 μg/mL. Flow Cytometry. Immunoprecipitation. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD59 Antibody Target Details CD59 Application Details Images back to top
|Buffer||PBS, pH 7.4 containing 15 mM Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
ImagesProduct Details anti-CD59 Antibody Target Details CD59 Application Details Handling back to top