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|Reactivity||Human, Pig (Porcine) Alternatives|
|Conjugate||This CD59 antibody is un-conjugated Alternatives|
Functional Studies (Func), Flow Cytometry (FACS)
|1 reference available|
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Product Details anti-CD59 AntibodyTarget Details CD59 Application Details Handling ProductDetails: References for anti-CD59 antibody (ABIN120694) Images
|Specificity||The antibody MEM-129 reacts with CD59 (Protectin).|
|Purification||Thiophilic Adsorption-Affinity Chromatography and Size-Exclusion Chromatography.|
|Purity||> 95 % (by SDS-PAGE).|
|Immunogen||Human peripheral blood lymphocytes|
Target Details CD59Product Details anti-CD59 Antibody Application Details Handling ProductDetails: References for anti-CD59 antibody (ABIN120694) Images back to top
|Alternative Name||CD59 (CD59 Antibody Abstract)|
|Background||CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin|
|Research Area||Cardiovascular, Atherosclerosis, Hematopoietic Progenitors, Tyrosine Kinases, Innate Immunity, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD59 Antibody Target Details CD59 Handling ProductDetails: References for anti-CD59 antibody (ABIN120694) Images back to top
Flow Cytometry. Functional Studies (The antibody activates T-cells).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD59 Antibody Target Details CD59 Application Details ProductDetails: References for anti-CD59 antibody (ABIN120694) Images back to top
|Buffer||Phosphate buffered saline (PBS), preserved by filter sterilization, approx. pH 7.4|
Store the antibody undiluted at 4-8 °C. DO NOT FREEZE! Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: one year from despatch.
|Expiry Date||12 months|
ProductDetails: References for anti-CD59 antibody (ABIN120694)Product Details anti-CD59 Antibody Target Details CD59 Application Details Handling Images back to top
Pizzo, Giurisato, Tassi, Benedetti, Pozzan, Viola: "Lipid rafts and T cell receptor signaling: a critical re-evaluation." in: European journal of immunology, Vol. 32, Issue 11, pp. 3082-91, 2003