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anti-Rat (Rattus) CD59 antibody for Functional Studies

Recommended CD59 Antibody (supplied by: Log in to see )

Antigen
CD59 Antibodies
  • 1F5
  • 16.3A5
  • AA987121
  • Cd59
  • Cd59a
  • Cd59b
  • EJ16
  • EJ30
  • EL32
  • G344
  • HRF-20
  • HRF20
  • MAC-IP
  • MACIF
  • MACIP
  • MEM43
  • MIC11
  • MIN1
  • MIN2
  • MIN3
  • MIRL
  • MSK21
  • p18-20
  • protectin
Reactivity
Rat (Rattus)
504
35
33
24
17
15
9
7
2
2
1
1
Host
Mouse
405
110
44
7
1
Clonality
Monoclonal
Conjugate
This CD59 antibody is un-conjugated
63
58
44
14
11
11
10
9
9
9
9
9
9
9
9
9
9
5
5
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Western Blotting (WB)
417
194
187
104
97
96
73
48
34
31
11
6
5
3
2
2
1
Supplier
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Catalog No. ABIN2192125
$ 515.62
Plus shipping costs $45.00

Top referenced anti-CD59 antibody for Functional Studies

Similar anti-CD59 Antibodies

Application / Reactivity Rat (Rattus)
ELISA 8 Antibodies
Flow Cytometry (FACS) 26 Antibodies
Functional Studies (Func) 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunohistochemistry (IHC) 3 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 1 Antibodies
Immunoprecipitation (IP) 24 Antibodies
Western Blotting (WB) 25 Antibodies

General

Antigen CD59 Antibodies
Reactivity Rat (Rattus)
(504), (35), (33), (24), (17), (15), (9), (7), (2), (2), (1), (1)
Host Mouse
(405), (110), (44), (7), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD59 antibody is un-conjugated
(63), (58), (44), (14), (11), (11), (10), (9), (9), (9), (9), (9), (9), (9), (9), (9), (9), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Western Blotting (WB)
(417), (194), (187), (104), (97), (96), (73), (48), (34), (31), (11), (6), (5), (3), (2), (2), (1)
Pubmed 3 references available
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Product Details anti-CD59 Antibody

Target Details CD59 Application Details Handling References for anti-CD59 Antibody (ABIN2192125) Images
Sterility 0.2 μm filtered
Clone TH9

Target Details CD59

Product Details anti-CD59 Antibody Application Details Handling References for anti-CD59 Antibody (ABIN2192125) Images back to top
Antigen
Alternative Name CD59 Glycoprotein (CD59 Antibody Abstract)
Background The monoclonal antibody TH9 recognizes rat CD59. Rat CD59 was previously known as rat inhibitory protein (RIP) and it is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 regulates the formation and function of the lytic C5b-9 complex by binding C8 and preventing the unfolding and membrane insertion of C9 and by binding C9 and restricting its polymerization.CD59 is a small (18 - 25 kDa) molecule, linked to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor and comprising 77 amino acids with a single N-linked carbohydrate group at Asn-18. Analogues of CD59 can be found in all species with similar structures and sizes. In rat, CD59 is expressed on vacular endothelium and circulating cells. In the central nervous system (CNS) of the rat, CD59 is expressed on the Schwann sheath of peripheral nerve fibres and on ependymal cells, but not on glial cells and neurons in the CNS. Rat astrocytes in vitro express CD59 on its surface. CD59 may be involved in rheumatoid arthritis, motor nerve injury in the Guillain-Barré sydrome and in other diseases where defective inhibition of complement activation on self tissue is involved. Furthermore, CD59 may play an important part in abrogating the effects of complement attack in renal disease. Its presence and protective effect have already been demonstrated on human renal cells. Aliases Membrane attack complex inhibition factor, MACIF, MAC-inhibitory protein, Protectin, CD59 Immunogen Partially purified (FPLC) rat CD59 prep (RIP)
Pathways Complement System

Application Details

Product Details anti-CD59 Antibody Target Details CD59 Handling References for anti-CD59 Antibody (ABIN2192125) Images back to top
Application Notes For immunohistology, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.
Restrictions For Research Use only

Handling

Product Details anti-CD59 Antibody Target Details CD59 Application Details References for anti-CD59 Antibody (ABIN2192125) Images back to top
Buffer PBS, containing 0.1 % bovine serum albumin.
Storage 4 °C
Storage Comment Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Expiry Date 12 months

References for anti-CD59 Antibody (ABIN2192125)

Product Details anti-CD59 Antibody Target Details CD59 Application Details Handling Images back to top
Product cited in:

Rogers, Gasque, Piddlesden, Okada, Holers, Morgan: "Expression and function of membrane regulators of complement on rat astrocytes in culture." in: Immunology, Vol. 88, Issue 1, pp. 153-61, 1996

Hughes, Meri, Davies, Williams, Morgan: "Immunolocalization and characterization of the rat analogue of human CD59 in kidney and glomerular cells." in: Immunology, Vol. 80, Issue 3, pp. 439-44, 1994

Hughes, Piddlesden, Williams, Harrison, Morgan: "Isolation and characterization of a membrane protein from rat erythrocytes which inhibits lysis by the membrane attack complex of rat complement." in: The Biochemical journal, Vol. 284 ( Pt 1), pp. 169-76, 1992