anti-Human Complement Factor H antibody for Immunohistochemistry (Frozen Sections)

Recommended Complement Factor H Antibody (supplied by: Log in to see )

Antigen
Complement Factor H (CFH) Antibodies
  • CFH
  • im:7147412
  • si:ch211-207o17.2
  • Mud-1
  • NOM
  • Sas-1
  • Sas1
  • AHUS1
  • AMBP1
  • ARMD4
  • ARMS1
  • CFHL3
  • FH
  • FHL1
  • HF
  • HF1
  • HF2
  • HUS
  • Fh
  • fH
  • complement factor H
  • complement component factor h
  • CFH
  • cfh
  • Cfh
Reactivity
Human
241
35
29
4
4
3
3
2
2
Host
Mouse
104
101
32
24
2
1
Clonality
Monoclonal
Conjugate
This Complement Factor H antibody is un-conjugated
20
14
6
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
177
151
61
43
37
26
26
22
12
10
10
9
6
5
4
2
1
1
1
1
1
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Catalog No. ABIN181114
$ 577.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN113379 ID IHC (fro) WB Sheep IgG Log in to see Polyclonal
1 ABIN2473067 IHC (fro) FACS ELISA WB Mouse IgG1 Log in to see 10-10 2
1 ABIN1858384 ICC IHC (fro) IHC (p) ELISA WB Mouse IgG AA 860-1231 Log in to see
1 ABIN204199 FACS IHC (fro) ELISA WB Mouse IgG1 Log in to see 10-10
1 ABIN206665 FACS IHC (fro) ELISA WB Mouse IgG1 Log in to see
1 ABIN4299974 ELISA FACS IHC IHC (fro) WB Mouse IgG1 Log in to see 10-10
1 ABIN640424 IHC (fro) FACS ELISA WB Mouse Log in to see

General

Antigen Complement Factor H (CFH) Antibodies
Reactivity Human
(241), (35), (29), (4), (4), (3), (3), (2), (2)
Host Mouse
(104), (101), (32), (24), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Complement Factor H antibody is un-conjugated
(20), (14), (6), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(177), (151), (61), (43), (37), (26), (26), (22), (12), (10), (10), (9), (6), (5), (4), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-Complement Factor H Antibody

Target Details Complement Factor H Application Details Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images
Specificity This antibody recognises Complement Factor H which exists in 2 forms.
Characteristics Synonyms: CFH, HF, HF1, HF2, H factor 1
Purification Affinity Chromatography on Protein A.
Immunogen Purified human factor H from serum.
Clone 10-10-14
Isotype IgG1

Target Details Complement Factor H

Product Details anti-Complement Factor H Antibody Application Details Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
Antigen
Background Complement factor H exists in 2 forms, the most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.Synonyms: CFH, H factor 1, HF, HF1, HF2
Gene ID 3075
UniProt P08603
Research Area Coagulation, Complement Factors
Pathways Complement System, Cellular Response to Molecule of Bacterial Origin

Application Details

Product Details anti-Complement Factor H Antibody Target Details Complement Factor H Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
Application Notes ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Complement Factor H Antibody Target Details Complement Factor H Application Details ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
Concentration 1.0 mg/mL
Buffer Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months

ProductDetails: References for anti-Complement Factor H antibody (ABIN181114)

Product Details anti-Complement Factor H Antibody Target Details Complement Factor H Application Details Handling Images back to top
Background publications

Alexander, Quigg: "The simple design of complement factor H: Looks can be deceiving." in: Molecular immunology, Vol. 44, Issue 1-3, pp. 123-32, 2006

Harrison, Lachmann: "The physiological breakdown of the third component of human complement." in: Molecular immunology, Vol. 17, Issue 1, pp. 9-20, 1980