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|Antigen||Complement Factor H (CFH) Antibodies|
|Conjugate||This Complement Factor H antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
|2 references available|
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Product Details anti-Complement Factor H AntibodyTarget Details Complement Factor H Application Details Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images
|Specificity||This antibody recognises Complement Factor H which exists in 2 forms.|
|Characteristics||Synonyms: CFH, HF, HF1, HF2, H factor 1|
|Purification||Affinity Chromatography on Protein A.|
|Immunogen||Purified human factor H from serum.|
Target Details Complement Factor HProduct Details anti-Complement Factor H Antibody Application Details Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
|Background||Complement factor H exists in 2 forms, the most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.Synonyms: CFH, H factor 1, HF, HF1, HF2|
|Research Area||Coagulation, Complement Factors|
|Pathways||Complement System, Cellular Response to Molecule of Bacterial Origin|
Application DetailsProduct Details anti-Complement Factor H Antibody Target Details Complement Factor H Handling ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Complement Factor H Antibody Target Details Complement Factor H Application Details ProductDetails: References for anti-Complement Factor H antibody (ABIN181114) Images back to top
|Buffer||Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
ProductDetails: References for anti-Complement Factor H antibody (ABIN181114)Product Details anti-Complement Factor H Antibody Target Details Complement Factor H Application Details Handling Images back to top
Alexander, Quigg: "The simple design of complement factor H: Looks can be deceiving." in: Molecular immunology, Vol. 44, Issue 1-3, pp. 123-32, 2006
Harrison, Lachmann: "The physiological breakdown of the third component of human complement." in: Molecular immunology, Vol. 17, Issue 1, pp. 9-20, 1980