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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN365061
Shi, Zhao, Liu, Zhang, Zhou, Pu: Serum proteomics of methamphetamine addicts and up-regulation of complement factor H related to methamphetamine addiction. in Neuroscience letters 2012
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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN414509
Lee, Park, Lee, Park, Shin, Park, Yoo, Cho, Kim, Kim, Namgoong, Lee, Lee, Cho, Han, Kang, Ha, Bae, Kim, Park, Cheong: Atypical hemolytic uremic syndrome: Korean pediatric series. in Pediatrics international : official journal of the Japan Pediatric Society 2015
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Human Complement Factor H ELISA Kit for Sandwich ELISA - ABIN511291
Lönnroth, Oshalim, Lange, Johansson: Interaction Of Proteasomes And Complement C3, Assay Of Antisecretory Factor In Blood. in Journal of immunoassay & immunochemistry 2015
Complement factor H Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2 (show ARMS2 ELISA Kits))/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (Meta-Analysis).
Regression analysis showed that ARMS2 (show ARMS2 ELISA Kits) TT genotype has a statistically significant effect on retinal angiomatous proliferation versus age-related macular degeneration compared to CFH genotypes (P < 0.001).
This study enclosed strong synergistic association of risk genotypes of C3 and CFH Y402H with AMD (show AMD1 ELISA Kits). We also revealed synergistic influence of CCL2 (show CCL2 ELISA Kits)-2518 and the at-risk genotype of the C3 in AMD (show AMD1 ELISA Kits) with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2 (show CCL2 ELISA Kits)-2518 polymorphism is not an innocent bystander (show SEPT1 ELISA Kits) in AMD (show AMD1 ELISA Kits) susceptibility when combined with the at-risk genotype of C3 (R102G).
Our results suggest that factor H can interfere with mycobacterial entry into macrophages and modulate inflammatory cytokine responses, particularly during the initial stages of infection, thus affecting the extracellular survival of the pathogen.
To our knowledge, this is the first evaluation of the involvement of the CFHR3 (show CFHR3 ELISA Kits)/CFHR1 (show CFHR1 ELISA Kits) deletion and age-related macular degeneration in CFH Y402H polymorphism Brazilian patients.
The findings of the present study provide evidence that CFH gene variants and ARMS2 (show ARMS2 ELISA Kits)/HTRA1 (show HTRA1 ELISA Kits) genes play a major role in the genetic susceptibility to AMD (show AMD1 ELISA Kits) in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD (show AMD1 ELISA Kits).
Our results suggest the contribution of all four predicted CFH polymorphisms in age-related macular degeneration (AMD (show AMD1 ELISA Kits)) susceptibility among the Iranian population. This association with CFH may lead to early detection and new strategies for prevention and treatment of AMD (show AMD1 ELISA Kits).
Development of polypoidal choroidal vasculopathy (PCV) in the unaffected fellow eye is associated with ARMS2 (show ARMS2 ELISA Kits) A69S genotype in patients with unilateral PCV.
Identification of rare CFH variant carriers may be important for upcoming complement-inhibiting therapies. Patients with an extensive drusen area, drusen with crystalline appearance, and drusen nasal to the optic disc are more likely to have a rare variant in the CFH gene.
C-reactive protein (show CRP ELISA Kits) amino acids 35-47 mediate the interaction with complement factor H in lupus nephritis
this study shows that complement regulatory protein (show TGFB1 ELISA Kits) Factor H is a soluble prion (show PRNP ELISA Kits) receptor that potentiates peripheral prion (show PRNP ELISA Kits) pathogenesis
Factor H and Crry (show CR1L ELISA Kits) are critical for regulating complement activation at distinct anatomic sites within the kidney.
VEGF (show VEGFA ELISA Kits) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (show KDR ELISA Kits)/PKC-alpha (show PKCa ELISA Kits)/CREB (show CREB1 ELISA Kits) signaling.
environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.
absence of plasma CfH conferred susceptibility to glomerulonephritis
This new understanding of the complicated interactions of CFH in AMD (show AMD1 ELISA Kits)-like pathology provides an improved foundation for the development of targeted therapies for AMD (show AMD1 ELISA Kits)
data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.
Cfh and Cfhr2 (show CFHR2 ELISA Kits) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.
A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.
Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (show MASP1 ELISA Kits) did not ameliorate either the plasma Complement C3 (show C3 ELISA Kits) (C3) activation or glomerular C3 accumulation in FH-deficient mice.
interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]
Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (show CFHR1 ELISA Kits)-4) in Danio rerio.
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
H factor 1 (complement)
, H factor 2 (complement)
, adrenomedullin binding protein
, age-related maculopathy susceptibility 1
, factor H
, factor H-like 1
, complement regulator factor H
, complement factor H
, complement factor H related protein 3A4/5G4
, protein beta-1-H
, complement component factor H
, complement inhibitory factor H
, platelet complement factor H
, complement factor H L homeolog