Browse our anti-Complement Factor I (CFI) Antibodies

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anti-Complement Factor I Antibodies (CFI)
On are 139 Complement Factor I (CFI) Antibodies from 20 different suppliers available. Additionally we are shipping Complement Factor I Kits (36) and Complement Factor I Proteins (17) and many more products for this protein. A total of 197 Complement Factor I products are currently listed.
AHUS3, C3b-INA, c3bc4bi, C3BINA, CFI, factor I, FI, gb:ai721528, IF, KAF, MGC53615

Most Popular Reactivities for anti-Complement Factor I (CFI) Antibodies

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anti-Mouse (Murine) Complement Factor I Antibodies:

anti-Human Complement Factor I Antibodies:

anti-Rat (Rattus) Complement Factor I Antibodies:

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Top referenced anti-Complement Factor I Antibodies

  1. Human Monoclonal Complement Factor I Primary Antibody for EIA, FACS - ABIN951647 : Kraus, James, Barclay: Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
    Show all 4 references for 951647

  2. Human Polyclonal Complement Factor I Primary Antibody for ELISA, WB - ABIN1451187 : Minta, Fung, Turner, Eren, Zemach, Rits, Goldberger: Cloning and characterization of the promoter for the human complement factor I (C3b/C4b inactivator) gene. in Gene 1998 (PubMed)
    Show all 2 references for 1451187

  3. Human Monoclonal Complement Factor I Primary Antibody for EIA, Func - ABIN181115 : Dragon-Durey, Frémeaux-Bacchi: Atypical haemolytic uraemic syndrome and mutations in complement regulator genes. in Springer seminars in immunopathology 2005 (PubMed)
    Show all 2 references for 181115

  4. Human Monoclonal Complement Factor I Primary Antibody for EIA, IP - ABIN118974 : Hsiung, Barclay, Brandon, Sim, Porter: Purification of human C3b inactivator by monoclonal-antibody affinity chromatography. in The Biochemical journal 1982 (PubMed)

  5. Human Monoclonal Complement Factor I Primary Antibody for FACS, IHC (p) - ABIN315441 : Crook, Hunt: Enrichment of early fetal-liver hemopoietic stem cells of the rat using monoclonal antibodies against the transferrin receptor, Thy-1, and MRC-OX82. in Developmental immunology 1996 (PubMed)

More Antibodies against Complement Factor I Interaction Partners

Mouse (Murine) Complement Factor I (CFI) interaction partners

  1. Factor I-mediated generation of activated C3 fragments in the circulation is a critical determinant for the development of MPGN2 associated with factor H (show CFH Antibodies) deficiency.

Human Complement Factor I (CFI) interaction partners

  1. Factor I binds C3b-Factor H (show CFH Antibodies) between Factor H (show CFH Antibodies) domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.

  2. Taken together, our data argue that multiple rare and ultra-rare alleles in CFI contribute to AMD (show AMD1 Antibodies) pathogenesis; they improve the precision of the assessment of the contribution of CFI to AMD (show AMD1 Antibodies)

  3. Case Report: thrombotic microangiopathy with mutations in complement factor I and thrombomodulin (show THBD Antibodies).

  4. Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome.

  5. Patients with advanced atrophic AMD (show AMD1 Antibodies) carried these rare variants more frequently than patients with neovascular AMD (show AMD1 Antibodies) (11 of 93 [11.8%] vs 40 of 835 [4.8%]; P = .04).

  6. Low FI levels are strongly associated with rare CFI variants and age-related macular degeneration.

  7. A missense variant (p.V412M) in CFI was discovered in two Tunisian Jewish families with early-onset age-related macular degeneration.

  8. Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H (show CFH Antibodies) and factor I, are not packaged in Weibel-Palade bodies.

  9. In this study, the odds of AMD (show AMD1 Antibodies) were highest in those with deficient vitamin D status and 2 risk alleles for the CFH (show CFH Antibodies) and CFI genotypes, suggesting a synergistic effect between vitamin D status and complement cascade protein function.

  10. association between rs10033900 and age-related macular degeneration risk in Han Chinese population

Complement Factor I (CFI) Antigen Profile

Antigen Summary

This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alternative names and synonyms associated with Complement Factor I (CFI)

  • complement factor I (cfi) antibody
  • Factor I C3b/C4b inactivator (serine protease) (Cfi) antibody
  • complement factor I (CFI) antibody
  • complement component factor i (Cfi) antibody
  • complement factor I (Cfi) antibody
  • complement factor I-like (LOC100516921) antibody
  • AHUS3 antibody
  • C3b-INA antibody
  • c3bc4bi antibody
  • C3BINA antibody
  • CFI antibody
  • factor I antibody
  • FI antibody
  • gb:ai721528 antibody
  • IF antibody
  • KAF antibody
  • MGC53615 antibody

Protein level used designations for CFI

complement factor I , I factor (complement) , complement factor 1 , C3B/C4B inactivator , C3b-inactivator , Konglutinogen-activating factor , complement component I , complement control protein factor I , complement factor I heavy chain , light chain of factor I , complement component 1

379108 Xenopus laevis
399318 Xenopus laevis
471271 Pan troglodytes
557557 Danio rerio
613100 Xenopus (Silurana) tropicalis
100072852 Equus caballus
100306949 Ictalurus punctatus
12630 Mus musculus
3426 Homo sapiens
79126 Rattus norvegicus
100338923 Oryctolagus cuniculus
100713918 Cavia porcellus
513197 Bos taurus
478515 Canis lupus familiaris
428773 Gallus gallus
101119307 Ovis aries
100174703 Pongo abelii
100516921 Sus scrofa
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