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anti-Human Complement Factor I antibody for Functional Studies

Recommended Complement Factor I Antibody (supplied by: Log in to see )

Antigen
Complement Factor I (CFI) Antibodies
  • AHUS3
  • ahus3
  • c3b-ina
  • C3b-INA
  • c3bc4bi
  • C3BINA
  • c3bina
  • Cfi
  • cfi
  • CFI
  • factor I
  • FI
  • gb:ai721528
  • IF
  • KAF
  • kaf
  • MGC53615
Reactivity
Human
128
1
Host
Mouse
97
29
2
1
Clonality
Monoclonal
Conjugate
This Complement Factor I antibody is un-conjugated
5
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
112
59
14
13
10
9
9
8
4
2
2
2
2
1
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Catalog No. ABIN181115
$ 698.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008771965 ABIN601092 Func IHC (fro) IHC (p) ELISA WB Mouse IgG1 Log in to see
0.0008771965 ABIN2473071 Func IHC (fro) ELISA WB Mouse IgG1 Log in to see 3R-8 2

Top referenced anti-Complement Factor I antibody for Functional Studies

Similar anti-Complement Factor I Antibodies

Application / Reactivity Human
ELISA 59 Antibodies
Enzyme Immunoassay (EIA) 9 Antibodies
Flow Cytometry (FACS) 9 Antibodies
Functional Studies (Func) 3 Antibodies
Immunocytochemistry (ICC) 2 Antibodies
Immunodiffusion (ID) 2 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunohistochemistry (IHC) 13 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies
Immunoprecipitation (IP) 14 Antibodies
Radioimmunoassay (RIA) 10 Antibodies
Western Blotting (WB) 113 Antibodies

General

Antigen Complement Factor I (CFI) Antibodies
Reactivity Human
(128), (1)
Host Mouse
(97), (29), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Complement Factor I antibody is un-conjugated
(5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(112), (59), (14), (13), (10), (9), (9), (8), (4), (2), (2), (2), (2), (1)
Pubmed 2 references available
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Product Details anti-Complement Factor I Antibody

Target Details Complement Factor I Application Details Handling References for anti-Complement Factor I Antibody (ABIN181115) Images
Specificity This antibody recognises complement factor I, a member of the peptidase S1 family present in the blood plasma.
Characteristics Synonyms: CFI, IF, KAF, AHUS3, C3BINA, C3b-INA, C3B/C4B inactivator
Purification Affinity chromatography on Protein A
Immunogen Native human factor I from serum.
Clone 3R-8
Isotype IgG1

Target Details Complement Factor I

Product Details anti-Complement Factor I Antibody Application Details Handling References for anti-Complement Factor I Antibody (ABIN181115) Images back to top
Antigen
Alternative Name Complement Factor I (CFI Antibody Abstract)
Background Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome.Synonyms: AHUS3, C3B/C4B inactivator, C3BINA, C3b-INA, CFI, IF, KAF
Gene ID 3426
UniProt P05156
Research Area Coagulation
Pathways Complement System

Application Details

Product Details anti-Complement Factor I Antibody Target Details Complement Factor I Handling References for anti-Complement Factor I Antibody (ABIN181115) Images back to top
Application Notes ELISA: 1/3000 - 1/4000. Western Blot. Functional Assays. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-Complement Factor I Antibody Target Details Complement Factor I Application Details References for anti-Complement Factor I Antibody (ABIN181115) Images back to top
Concentration 1.0mg/mL
Buffer Borate buffered saline pH 8.4 containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months

References for anti-Complement Factor I Antibody (ABIN181115)

Product Details anti-Complement Factor I Antibody Target Details Complement Factor I Application Details Handling Images back to top
Background publications

Nilsson, Karpman, Vaziri-Sani, Kristoffersson, Salomon, Provot, Fremeaux-Bacchi, Trouw, Blom: "A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation." in: Molecular immunology, Vol. 44, Issue 8, pp. 1835-44, 2006

Dragon-Durey, Frémeaux-Bacchi: "Atypical haemolytic uraemic syndrome and mutations in complement regulator genes." in: Springer seminars in immunopathology, Vol. 27, Issue 3, pp. 359-74, 2005