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anti-Human CR1 antibody for Intracellular Flow Cytometry

Recommended CR1 Antibody (supplied by: Log in to see )

Antigen
Complement Component Receptor 1 (CD35) (CR1) Antibodies
  • C3BR
  • C3DR
  • C4BR
  • CD21
  • CD35
  • Cr-1
  • Cr-2
  • Cr1
  • KN
Reactivity
Human
293
61
46
46
41
10
10
5
2
Host
Mouse
264
71
2
Clonality
Monoclonal
Conjugate
This CR1 antibody is conjugated to FITC
36
36
16
8
8
7
7
7
6
6
6
6
6
6
6
6
6
6
3
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
280
179
132
125
85
68
67
63
35
11
11
4
4
3
2
2
1
1
1
1
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Catalog No. ABIN2661688
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Top referenced anti-CR1 antibody for Intracellular Flow Cytometry

Similar anti-CR1 Antibodies

Application / Reactivity Human
ELISA 35 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 239 Antibodies
Functional Studies (Func) 1 Antibodies
Immunoassay (IA) 2 Antibodies
Immunocytochemistry (ICC) 63 Antibodies
Immunofluorescence (IF) 68 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 68 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 4 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 4 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 11 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 84 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 132 Antibodies
Immunohistochemistry (Paraformaldehyde) (IHC (pfa)) 1 Antibodies
Immunoprecipitation (IP) 80 Antibodies
Intracellular Flow Cytometry (ICFC) 1 Antibodies

General

Antigen Complement Component Receptor 1 (CD35) (CR1) Antibodies
Reactivity Human
(293), (61), (46), (46), (41), (10), (10), (5), (2)
Host Mouse
(264), (71), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CR1 antibody is conjugated to FITC
(36), (36), (16), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
(280), (179), (132), (125), (85), (68), (67), (63), (35), (11), (11), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-CR1 Antibody

Target Details CR1 Application Details Handling References for anti-CR1 Antibody (ABIN2661688) Images
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone E11
Isotype IgG1 kappa

Target Details CR1

Product Details anti-CR1 Antibody Application Details Handling References for anti-CR1 Antibody (ABIN2661688) Images back to top
Antigen
Alternative Name CD35 (CR1 Antibody Abstract)
Background CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Complement System

Application Details

Product Details anti-CR1 Antibody Target Details CR1 Handling References for anti-CR1 Antibody (ABIN2661688) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CR1 Antibody Target Details CR1 Application Details References for anti-CR1 Antibody (ABIN2661688) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CR1 Antibody (ABIN2661688)

Product Details anti-CR1 Antibody Target Details CR1 Application Details Handling Images back to top
Background publications

Marinho, Azeredo, Torrentes-Carvalho, Marins-Dos-Santos, Kubelka, de Souza, Cunha, de-Oliveira-Pinto: "Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection." in: PLoS ONE, Vol. 9, Issue 7, pp. e102014, 2014

Zabaleta, Arias, Maya, García: "Diminished adherence and/or ingestion of virulent Mycobacterium tuberculosis by monocyte-derived macrophages from patients with tuberculosis." in: Clinical and diagnostic laboratory immunology, Vol. 5, Issue 5, pp. 690-4, 1998

Pascual, Danielsson, Steiger, Schifferli: "Proteolytic cleavage of CR1 on human erythrocytes in vivo: evidence for enhanced cleavage in AIDS." in: European journal of immunology, Vol. 24, Issue 3, pp. 702-8, 1994

Klickstein, Bartow, Miletic, Rabson, Smith, Fearon: "Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis." in: The Journal of experimental medicine, Vol. 168, Issue 5, pp. 1699-717, 1988

Hogg, Ross, Jones, Slusarenko, Walport, Lachmann: "Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1)." in: European journal of immunology, Vol. 14, Issue 3, pp. 236-43, 1984

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-CR1 antibody (Complement Component Receptor 1 (CD35))  (FITC) (ABIN2661688) anti-Complement Component Receptor 1 (CD35) (CR1) antibody (FITC)