anti-Human CR1 antibody for Immunohistochemistry (Formalin-fixed Sections)

Recommended CR1 Antibody (supplied by: Log in to see )

Antigen
Complement Component Receptor 1 (CD35) (CR1) Antibodies
  • C3BR
  • C4BR
  • CD35
  • KN
  • C3DR
  • CD21
  • Cr-1
  • Cr-2
  • Cr1
  • complement component (3b/4b) receptor 1 (Knops blood group)
  • complement component (3d/Epstein Barr virus) receptor 2
  • complement receptor 2
  • complement receptor type 1-like
  • CR1
  • CR2
  • Cr2
  • LOC100514723
Reactivity
Human, Non-Human Primate
308
70
51
47
46
17
15
2
2
Host
Mouse
272
78
2
Clonality
Monoclonal
Conjugate
This CR1 antibody is conjugated to PE
35
33
15
10
10
9
9
7
7
6
6
6
6
6
6
6
6
4
4
4
4
3
1
1
1
1
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
268
159
121
104
68
66
50
47
39
13
11
8
6
2
2
2
1
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Catalog No. ABIN2749129
$ 334.95
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2749062 IHC (f) ICC FACS IP IHC (p) WB Mouse IgG1 Log in to see E11 2
1 ABIN2749128 IHC (f) ICC FACS IP IHC (p) WB FITC Mouse IgG1 Log in to see E11 2
1 ABIN2144575 IHC (f) ICC FACS IP IHC (p) WB FITC Mouse IgG1 Log in to see 4AE11
1 ABIN2144577 IHC (f) ICC FACS IP IHC (p) WB FITC Mouse IgG1 Log in to see 4AE11
1 ABIN2144862 IHC (f) ICC FACS IP IHC (p) WB PE Mouse IgG1 Log in to see 4AE11
1 ABIN2144864 IHC (f) ICC FACS IP IHC (p) WB PE Mouse IgG1 Log in to see 4AE11
1 ABIN1099623 IHC (f) FACS WB Mouse IgG1 Log in to see To5
1 ABIN1099625 IHC (f) FACS WB Biotin Mouse IgG1 Log in to see To5

General

Antigen Complement Component Receptor 1 (CD35) (CR1) Antibodies
Reactivity Human, Non-Human Primate
(308), (70), (51), (47), (46), (17), (15), (2), (2)
Host Mouse
(272), (78), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CR1 antibody is conjugated to PE
(35), (33), (15), (10), (10), (9), (9), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(268), (159), (121), (104), (68), (66), (50), (47), (39), (13), (11), (8), (6), (2), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
Supplier Log in to see

Product Details anti-CR1 Antibody

Target Details CR1 Application Details Handling References for anti-CR1 antibody (ABIN2749129) Images
Specificity The mouse monoclonal antibody E11 recognizes CD35 (CR1), a type I glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes.
HLDA III, WS Code 204
Characteristics The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Immunogen Acute monocytic leukemia cells and normal blood monocytes
Clone E11
Isotype IgG1

Target Details CR1

Product Details anti-CR1 Antibody Application Details Handling References for anti-CR1 antibody (ABIN2749129) Images back to top
Antigen
Alternative Name CD35 (CR1 Antibody Abstract)
Background CD35 (complement receptor 1, CR1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-CR1 Antibody Target Details CR1 Handling References for anti-CR1 antibody (ABIN2749129) Images back to top
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests.
Restrictions For Research Use only

Handling

Product Details anti-CR1 Antibody Target Details CR1 Application Details References for anti-CR1 antibody (ABIN2749129) Images back to top
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

References for anti-CR1 antibody (ABIN2749129)

Product Details anti-CR1 Antibody Target Details CR1 Application Details Handling Images back to top
Background publications

Kremlitzka, Polgár, Fülöp, Kiss, Poór, Erdei: "Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients." in: International immunology, Vol. 25, Issue 1, pp. 25-33, 2013

Nielsen, Pedersen, Marquart, Prodinger, Leslie: "The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells." in: European journal of immunology, Vol. 32, Issue 5, pp. 1359-67, 2002

Product cited in:

Hogg, Ross, Jones, Slusarenko, Walport, Lachmann: "Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1)." in: European journal of immunology, Vol. 14, Issue 3, pp. 236-43, 1984