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anti-Non-Human Primate CR1 antibody for Flow Cytometry

Recommended CR1 Antibody (supplied by: Log in to see )

Antigen
Complement Component Receptor 1 (CD35) (CR1) Antibodies
  • C3BR
  • C3DR
  • C4BR
  • CD21
  • CD35
  • Cr-1
  • Cr-2
  • Cr1
  • KN
Reactivity
Human, Non-Human Primate
193
17
14
10
10
6
4
2
Host
Mouse
167
28
2
Clonality
Monoclonal
Conjugate
This CR1 antibody is conjugated to APC
33
30
10
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
148
76
60
42
42
38
21
20
11
11
11
4
4
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2678717
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.3068567 ABIN2678716 FACS FITC Mouse IgG1 kappa Log in to see E11
0.0010666476 ABIN2749062 IHC (f) ICC FACS IP IHC (p) WB Mouse IgG1 Log in to see E11 2
0.0010666476 ABIN2749128 IHC (f) ICC FACS IP IHC (p) WB FITC Mouse IgG1 Log in to see E11 2
0.0010666476 ABIN2749129 IHC (f) ICC FACS IP IHC (p) WB PE Mouse IgG1 Log in to see E11 3

Top referenced anti-CR1 antibody for Flow Cytometry

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General

Antigen Complement Component Receptor 1 (CD35) (CR1) Antibodies
Reactivity Human, Non-Human Primate
(193), (17), (14), (10), (10), (6), (4), (2)
Host Mouse
(167), (28), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CR1 antibody is conjugated to APC
(33), (30), (10), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(148), (76), (60), (42), (42), (38), (21), (20), (11), (11), (11), (4), (4), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-CR1 Antibody

Target Details CR1 Application Details Handling References for anti-CR1 Antibody (ABIN2678717) Images
Specificity This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively, in the classical and alternative complement pathways. In humans, CD35 has been implicated in a variety of roles, including complement activation, transporting C3 complexes on erythrocytes, phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization. Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis.

The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus monkey, olive baboon, and rhesus macaque.
Characteristics This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively, in the classical and alternative complement pathways. In humans, CD35 has been implicated in a variety of roles, including complement activation, transporting C3 complexes on erythrocytes, phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization. Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis. The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus monkey, olive baboon, and rhesus macaque.
Synonyms: Synonyms: Complement receptor 1, CR1, C3b/C4b receptor
Clone E11
Isotype IgG1 kappa

Target Details CR1

Product Details anti-CR1 Antibody Application Details Handling References for anti-CR1 Antibody (ABIN2678717) Images back to top
Antigen
Alternative Name CD35 (CR1 Antibody Abstract)
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Complement System

Application Details

Product Details anti-CR1 Antibody Target Details CR1 Handling References for anti-CR1 Antibody (ABIN2678717) Images back to top
Application Notes Applications reported: This E11 antibody has been reported for use in flow cytometric analysis.

Applications tested: This E11 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10 5 to 10 8 cells/test.
Restrictions For Research Use only

Handling

Product Details anti-CR1 Antibody Target Details CR1 Application Details References for anti-CR1 Antibody (ABIN2678717) Images back to top
Buffer aqueous buffer, 0.09 % sodium azide, may contain carrier protein/stabilizer
Handling Advice Do not freeze. Light-sensitive material.
Storage 4 °C
Storage Comment Store at 2-8°C.

References for anti-CR1 Antibody (ABIN2678717)

Product Details anti-CR1 Antibody Target Details CR1 Application Details Handling Images back to top
Product cited in:

Glodek, Mirchev, Golan, Khoory, Burns, Shevkoplyas, Nicholson-Weller, Ghiran: "Ligation of complement receptor 1 increases erythrocyte membrane deformability." in: Blood, Vol. 116, Issue 26, pp. 6063-71, 2010

Images

Product Details anti-CR1 Antibody Target Details CR1 Application Details Handling References for anti-CR1 Antibody (ABIN2678717) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-CR1 antibody (Complement Component Receptor 1 (CD35))  (APC) (ABIN2678717) anti-Complement Component Receptor 1 (CD35) (CR1) antibody (APC)