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Browse our Kallikrein 6 Proteins (KLK6)

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Kallikrein 6 Proteins (KLK6)
On are 24 Kallikrein 6 (KLK6) Proteins from 10 different suppliers available. Additionally we are shipping Kallikrein 6 Antibodies (93) and Kallikrein 6 Kits (49) and many more products for this protein. A total of 180 Kallikrein 6 products are currently listed.
AI849898, BSP, Bssp, hK6, Klk1b21, Klk6, Klk7, KLK8, Klk29, MSP, neurosin, PRSS9, PRSS18, rGK-8, rk8, SP59
list all proteins Gene Name GeneID UniProt
KLK6 292866 P36374
KLK6 19144  
KLK6 5653 Q92876

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Kallikrein 6 Proteins (KLK6) by Origin

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Top referenced Kallikrein 6 Proteins

  1. Human Kallikrein 6 Protein expressed in Human Cells - ABIN2005065 : Nathalie, Chris, Serge, Catherine, Benjamin, Claire, Christelle, Briollais, Pascale, Marie-Lise, Yves: High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. in Journal of cellular and molecular medicine 2010 (PubMed)
    Show all 2 references for ABIN2005065

  2. Human Kallikrein 6 Protein expressed in HEK-293 Cells - ABIN2181439 : Ashby, Kehoe, Love: Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia. in Brain research 2010 (PubMed)

More Proteins for Kallikrein 6 Interaction Partners

Mouse (Murine) Kallikrein 6 (KLK6) interaction partners

  1. KLK6 (show KLK1 Proteins) protein from 129 mice showed reduced SDS (show SDS Proteins)-PAGE mobility compared with that from C57BL/6 mice; recombinant KLK6 (show KLK1 Proteins) protein from 129 mice had a higher optimum pH and >15 times higher hydrolytic enzymatic activity for several substrates than that from C57BL/6 mice. These results suggest that KLKs may contribute to the genetic basis of the differences between mouse strains.

  2. these data point to a novel kallikrein 6 (show KLK1 Proteins) -signaling axis in neurons that is mediated by PAR1 (show F2R Proteins) and PAR2 (show F2RL1 Proteins) and is positioned to contribute to neurodegeneration

  3. These results indicate that KLK6 (show KLK1 Proteins) plays a functional role in oligodendrocyte development and the expression of myelin proteins.

  4. Neuropathological analysis following delivery of LV-Neurosin to alpha-syn tg mice resulted in reduced accumulation of alpha-syn and reversal of neurodegenerative alterations in wild type but not A53T alpha-syn tg mice

  5. We have found an increase in the level of neurosin, a key negative regulator of SNCA in the Ts65Dn mouse model for Down syndrome

  6. KLK6 (show KLK1 Proteins) is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis

  7. Klk8 is involved in the proliferation and migration of keratinocytes through Klk6 (show KLK1 Proteins) in the early stages of wound healing, and possibly in keratinocyte differentiation associated with the upregulation of PAR2 (show F2RL1 Proteins) in the late stages of wound healing.

  8. neurosin plays a significant role in physiological alpha-synuclein degradation and also in the pathogenesis of synucleinopathies

  9. study demonstrates changes in the expression of neuropsin (show KLK8 Proteins) and protease M/neurosin in oligodendrocytes following hemisection of the spinal cord

  10. Myofibril-bound serine protease (show F2 Proteins) and its endogenous inhibitor in mouse: extraction, partial characterization and effect on myofibrils (Protease M)

Human Kallikrein 6 (KLK6) interaction partners

  1. Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival.

  2. Data indicate that elevated expression of microRNA-375 in head and neck squamous cell carcinoma (HNSCC) cells significantly reduces kallikrein 6 (KLK6), kallikrein 10 (KLK10 (show KLK10 Proteins)), and matrix metalloproteinase 9 (MMP9 (show MMP9 Proteins)) messenger RNA expression.

  3. KLK6 (show KLK1 Proteins) expression was detected in head and neck tumor cell lines (FaDu, Cal27 and SCC25), but not in HeLa cervix carcinoma cells.

  4. KLK6 (show KLK1 Proteins) and KLK7 (show KLK7 Proteins) mRNA and protein overexpression is directly associated with early-stage ovarian tumors.

  5. The results of this study indicated that reductions in kallikrein-6 and calpain-1 may contribute to the accumulation of alpha-synuclein in DLB.

  6. KLK6 (show KLK1 Proteins) and KLK10 (show KLK10 Proteins) may be useful markers and potential therapeutic targets in gastroesophageal junction tumors

  7. This study assessed the prognostic utility of human tissue kallikrein (show KLK1 Proteins)-like peptidases 6 and 10 (KLK6 (show KLK1 Proteins) and KLK10 (show KLK10 Proteins)) and correlated their expression with histopathological and clinical parameters in gastric cancer.

  8. KLK6 (show KLK1 Proteins) may represent a potential unfavorable prognostic biomarker for colon cancer.

  9. KLK6 (show KLK1 Proteins) promotes the proliferation of lung tumoral cells and restrains their apoptosis in vitro via ligand-dependent EGFR (show EGFR Proteins) and was dependent on the protease-activated receptor 2 (show F2RL1 Proteins).

  10. The level of KLK6 (show KLK1 Proteins) is significantly increased in the plasma samples from laryngeal cancer patients compared to the controls.

Kallikrein 6 (KLK6) Protein Profile

Protein Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.

Alternative names and synonyms associated with Kallikrein 6 (KLK6)

  • kallikrein 6 (klk6)
  • kallikrein 1-related peptidase C8 (Klk1c8)
  • kallikrein related-peptidase 6 (Klk6)
  • kallikrein-related peptidase 6 (KLK6)
  • kallikrein-related peptidase 6 (Klk6)
  • AI849898 protein
  • BSP protein
  • Bssp protein
  • hK6 protein
  • Klk1b21 protein
  • Klk6 protein
  • Klk7 protein
  • KLK8 protein
  • Klk29 protein
  • MSP protein
  • neurosin protein
  • PRSS9 protein
  • PRSS18 protein
  • rGK-8 protein
  • rk8 protein
  • SP59 protein

Protein level used designations for Kallikrein 6 Proteins (KLK6)

kallikrein 6 , P1 Kallikrein , glandular kallikrein-8 , kallikrein 1-related peptidase b21 , prostatic glandular kallikrein-6 , serine protease , tissue kallikrein , brain serine protease , kallikrein 29 , myelencephalon-specific protease , myofibril-bound protease , protease M , protease, serine, 18 , protease, serine, 9 , kallikrein 6 (neurosin) , kallikrein 6 (neurosin, zyme) , kallikrein-6 , protease serine 9 (neurosin) , neurosin , serine protease 18 , serine protease 9 , zyme

496635 Xenopus (Silurana) tropicalis
292866 Rattus norvegicus
19144 Mus musculus
29245 Rattus norvegicus
5653 Homo sapiens
532677 Bos taurus
476402 Canis lupus familiaris
100716801 Cavia porcellus
101113520 Ovis aries
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