Browse our KLKB1 Proteins (KLKB1)

On are 19 Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) Proteins from 6 different suppliers available. Additionally we are shipping KLKB1 Antibodies (108) and KLKB1 Kits (12) and many more products for this protein. A total of 146 KLKB1 products are currently listed.
Aps, DKFZp459J2015, hK3, Kal-3, Kal3, Kalp1, KALP15, KLK2A1, Klk3, KLKB1, PPK, PSA
list all proteins Gene Name GeneID UniProt
KLKB1 354 P07288
KLKB1 16621 P26262
KLKB1 25048  

KLKB1 Proteins (KLKB1) by Origin

More Proteins for KLKB1 Interaction Partners

Human Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) interaction partners

  1. these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease-activated receptor 1 (show F2R Proteins)

  2. von Willebrand factor (show VWF Proteins) activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth.

  3. KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia.

  4. Genotyping these subjects revealed that the carriers of the minor alleles at the two loci- F12 (show F12 Proteins) and KLKB1 had a significant association with reduced levels of active plasma renin (show REN Proteins).

  5. 2 genetic loci (kininogen 1 (show KNG1 Proteins) and kallikrein (show KLK4 Proteins) B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein (show KLK4 Proteins)-kinin system and the RAAS.

  6. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation.

  7. FXI (show F11 Proteins) may have a role in risk of ischemic stroke, but not myocardial infarct; FXII (show F12 Proteins) and prekallikrein may not have a role in either

  8. plasma kallikrein and FXIa activate pro-HGF (show HGF Proteins) in vitro

  9. the effect of kininogen (show KNG1 Proteins) degradation by human neutrophil elastase (HNE (show ELANE Proteins)) on kinin generation by tissue and plasma kallikreins.

  10. Crystallization and x-ray crystal structure determination have yielded the first three-dimensional views of the catalytic domain of plasma kallikrein

Mouse (Murine) Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) interaction partners

  1. Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator (show PLAT Proteins) therapy in mice after stroke.

  2. we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3 (show PSA Proteins)) and other kallikrein (show KLK1 Proteins)-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins

  3. Klkb1(-/-) mice have a novel mechanism for thrombosis protection in addition to reduced contact activation. This pathway arises when bradykinin delivery to vasculature is compromised and mediated by increased receptor Mas (show MAS1 Proteins), prostacyclin, Sirt1 (show SIRT1 Proteins), and KLF4 (show KLF4 Proteins)

  4. Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.

  5. PKK (show RIPK4 Proteins) or fXII (show F12 Proteins) deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis.

  6. Data suggest that LGG secreting PSA (show NPEPPS Proteins) may activate antigen specific immune responses when instilled intravesically and IL15 (show IL15 Proteins) could enhance this response.

  7. the prekallikrein gene (Klkb1) is expressed highly in the mammary gland during stromal remodeling periods including puberty and postlactational involution.

KLKB1 Protein Profile

Protein Summary

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Alternative names and synonyms associated with KLKB1

  • kallikrein-related peptidase 3 (KLK3)
  • kallikrein B, plasma (Fletcher factor) 1 (KLKB1)
  • kallikrein B, plasma 1 (Klkb1)
  • plasma kallikrein (CpipJ_CPIJ004042)
  • plasma kallikrein (CpipJ_CPIJ014955)
  • plasma kallikrein (CpipJ_CPIJ020108)
  • Plasma kallikrein (VAA_02266)
  • kallikrein B, plasma (Fletcher factor) 1 (klkb1)
  • SH2B adaptor protein 2 (Sh2b2)
  • Aps protein
  • DKFZp459J2015 protein
  • hK3 protein
  • Kal-3 protein
  • Kal3 protein
  • Kalp1 protein
  • KALP15 protein
  • KLK2A1 protein
  • Klk3 protein
  • KLKB1 protein
  • PPK protein
  • PSA protein

Protein level used designations for KLKB1

P-30 antigen , gamma-seminoprotein , kallikrein-3 , prostate specific antigen , prostate-specific antigen , semenogelase , seminin , Fletcher factor , kininogenin , plasma kallikrein , plasma kallikrein heavy chain , plasma kallikrein light chain , plasma prekallikrein , antigen, prostate specific , fletcher factor , kallikrein 3, plasma , kallikrein B, plasma (Fletcher factor) 1 , Plasma kallikrein , plasma kallikrein-like , SH2 and PH domain-containing adapter protein APS , SH2B adapter protein 2 , adapter protein with pleckstrin homology and Src homology 2 domains , adaptor protein with pleckstrin homology and src homology 2 domains

354 Homo sapiens
3818 Homo sapiens
16621 Mus musculus
25048 Rattus norvegicus
471375 Pan troglodytes
475624 Canis lupus familiaris
6035439 Culex quinquefasciatus
6049018 Culex quinquefasciatus
6054508 Culex quinquefasciatus
10775770 Vibrio anguillarum 775
100056650 Equus caballus
100173876 Pongo abelii
100468355 Ailuropoda melanoleuca
100549617 Meleagris gallopavo
100557428 Anolis carolinensis
100594044 Nomascus leucogenys
114203 Rattus norvegicus
397144 Sus scrofa
533547 Bos taurus
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