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The results of this study show that MASP-2 contributes to severity and outcome in pneumococcal meningitis. In patients with pneumococcal meningitis, MASP-2 concentration was elevated in the CSF (show CSF2 Proteins) and high levels were associated with poor functional outcome.
Genetically determined MASP-2 levels seem to have a two-edge effect in HIV and probably HCV/HBV coinfection, whereas low levels increase the susceptibility to infection, but on the other side protects against AIDS.
MASP-2 was not associated with adverse cardiovascular outcomes in diabetics.
This is the first comprehensive meta-analysis indicates that the MASP-2 functional gene (rs72550870) polymorphism is not associated with the infection diseases, and the key functional gene polymorphism of rs72550870 did not increase susceptibility to the infection diseases.
This study suggests that hMASP-2 can induce a protective efficacy in BCG (show SLC11A1 Proteins)-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them.
The ficolin-3 (show FCN3 Proteins)/MASP-2 complex was significantly lower in the cardiac syndrome X patients compared to controls.
MASP-1 (show MASP1 Proteins) and MASP-2 are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.
MBL2 (show MBL2 Proteins) and MASP2 deficiencies protect against the development of systemic inflammatory response after pediatric cardiac surgery.
Data show that the vector expressing mannose-binding lectin (show MBL2 Proteins) associated protein 19 (MAp19) has been prepared successfully, and can express the target protein (MAp19) in the eukaryotic cells (HeLa cells).
polymorphism of MASP-2 (rs6695096) gene was associated with susceptibility to tuberculosis.
MASP-2 has an essential role in the mediation of cerebral ischemia-reperfusion injury.
this study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis
We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway.
Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.
Gene targeting of mouse TDP-43 (show TARDBP Proteins) negatively affects Masp2 expression.
ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR (show C3AR1 Proteins) and C5aR (show C5AR1 Proteins).
study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of mannan-binding lectin-independent lectin pathway activation in the host defense against pneumococci
Targeting of mannan-binding lectin (show MBL2 Proteins)-associated serine protease-2 (show PRSS2 Proteins) confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.
Recombinant protein of masp2 was made and purified.
MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway.
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.
MBL-associated plasma protein of 19 kD
, MBL-associated serine protease 2
, mannan-binding lectin serine peptidase 1 pseudogene 1
, mannan-binding lectin serine protease 1 pseudogene 1
, mannan-binding lectin serine protease 2
, mannose-binding protein-associated serine protease 2
, small MBL-associated protein
, mannose binding lectin-associated serine protease-2