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|Antigen||Plasminogen (PLG) Antibodies|
|Conjugate||This PLG antibody is conjugated to HRP Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
|1 reference available|
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Product Details anti-PLG AntibodyTarget Details PLG Application Details Handling ProductDetails: References for anti-PLG antibody (ABIN336225) Images
|Specificity||Minimal reactivity with related serum proteins. May react with Plasminogen from other species.|
|Immunogen||Highly pure human Plasminogen.|
Target Details PLGProduct Details anti-PLG Antibody Application Details Handling ProductDetails: References for anti-PLG antibody (ABIN336225) Images back to top
|Alternative Name||Plasminogen / PLG (PLG Antibody Abstract)|
|Background||Human plasminogen is a 92 kDa single-chain glycoprotein and inactive precursor (zymogen) of plasmin, secreted by the liver and present in the blood and majority of extravascular body fluids. Plasminogen is the central component in the fibrinolytic system, and is converted into active plasmin through cleavage by the endogenous activators urokinase (u-PA) and tissue plasminogen activator (t-PA), in the presence of fibrin. The level of plasminogen is maintained in the plasma at around 200 mg/L, with an increase being associated with hypothyroidism, obesity and pregnancy, and deficiencies with many disorders including thrombosis, liver disease, sepsis and hyperthyroidism.|
|Research Area||Cancer, Angiogenesis, Cytokines|
Application DetailsProduct Details anti-PLG Antibody Target Details PLG Handling ProductDetails: References for anti-PLG antibody (ABIN336225) Images back to top
Immunohistochemistry: 1/10-1/50. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-PLG Antibody Target Details PLG Application Details ProductDetails: References for anti-PLG antibody (ABIN336225) Images back to top
|Buffer||PBS, pH 7.4 containing 0.01 % Thiomersal as preservative.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ProductDetails: References for anti-PLG antibody (ABIN336225)Product Details anti-PLG Antibody Target Details PLG Application Details Handling Images back to top
Fears: "Binding of plasminogen activators to fibrin: characterization and pharmacological consequences." in: The Biochemical journal, Vol. 261, Issue 2, pp. 313-24, 1989