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Stewart, Nijmeh, Brightling, Sayers: uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium. in Thorax 2012
Show all 4 Pubmed References
Human PLG ELISA Kit for Sandwich ELISA - ABIN416924
Wang, Yuan, Zhong, Wen, Deng, Liang, Zheng: The anticoagulant effect of PGI2S and tPA in transgenic umbilical vein endothelial cells is linked to up-regulation of PKA and PKC. in International journal of molecular sciences 2014
Mouse (Murine) PLG ELISA Kit for Sandwich ELISA - ABIN820647
Ly, Taylor, Tsatsaronis, Monteleone, Skora, Donald, Maddocks, Nizet, West, Ranson, Walker, McArthur, Sanderson-Smith: Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing. in Journal of innate immunity 2014
Human PLG ELISA Kit for Sandwich ELISA - ABIN612752
Forsgren, Råden, Israelsson, Larsson, Hedén: Molecular cloning and characterization of a full-length cDNA clone for human plasminogen. in FEBS letters 1987
Show all 4 Pubmed References
Human PLG ELISA Kit for Sandwich ELISA - ABIN780340
Andersen, Friis, Hansen, Svenningsen, Henriksen, Jensen: Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2015
Ikezoe, Yang, Nishioka, Isaka, Iwabu, Sakai, Taniguchi, Honda, Yokoyama: Thrombomodulin enhances the antifibrinolytic and antileukemic effects of all-trans retinoic acid in acute promyelocytic leukemia cells. in Experimental hematology 2012
Data suggest that protein aggregates interact with tissue-type plasminogen activator (show PLAT ELISA Kits) and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin (show Alpha2 Antiplasmin ELISA Kits) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
The mechanism for plasminogen/M protein (show MYOM2 ELISA Kits) binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management
t-PA (show PLAT ELISA Kits) binds to Lys91 in the MBP (show MBL2 ELISA Kits) NH2-terminal region and PLG binds to Lys122 in the MBP (show MBL2 ELISA Kits) COOH-terminal region. This proximity promotes the activation of PLG by t-PA (show PLAT ELISA Kits).
in the presence of platelet polyphosphate and the downstream substrate fibrin, alphaFXIIa is a highly efficient and favorable plasminogen activator.
Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer
Our findings indicate a new pathway for bradykinin formation in patients with HAE, in which FXII (show F12 ELISA Kits) is cleaved and activated by plasmin.
VWF (show VWF ELISA Kits) susceptibility to plasmin proteolysis at K1491-R1492 is modulated by local N-linked glycan expression within A1A2A3, and specifically inhibited by heparin binding to the A1 domain.
Plasminogen and P4HA2 (show P4HA2 ELISA Kits) are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis
Plasminogen and OxPL-PLG were lower in patients presenting with an acute MI than in those with stable CAD (show CAD ELISA Kits) and also in those with atherothrombotic MI (Type 1) vs. those with non-atherothrombotic MI (Type 2).
Although carriers with PLG:p.Ala620Thr show low plasminogen activity, this is not a predisposing variant for aHUS; and individuals of dysplasminogenemia are not at significantly increased risk of aHUS.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (show TNF ELISA Kits)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS (show TLR4 ELISA Kits) via annexin A1 (show ANXA1 ELISA Kits).
findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS (show MAS1 ELISA Kits)) and a potential novel therapeutic target for MAS (show MAS1 ELISA Kits).
Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.
Plasminogen may regulate DPP-4 (show DPP4 ELISA Kits) activity and glucose metabolism.
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (show SLC11A2 ELISA Kits) C (show PROC ELISA Kits) (MntC) is an extracellular matrix- and plasminogen-binding protein (show ENO1 ELISA Kits)
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 ELISA Kits)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
plg-/- and tPA (show PLAT ELISA Kits)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B