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anti-Rat (Rattus) GNA13 Antibodies:
anti-Human GNA13 Antibodies:
anti-Mouse (Murine) GNA13 Antibodies:
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Human Polyclonal GNA13 Primary Antibody for WB - ABIN1537979
Zhang, Xu, Lu, Liu, Liu, Ji, Liu, Ouyang, He: VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation. in PLoS ONE 2014
In embryos defective for S1pr2 (show S1PR2 Antibodies)/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Gpr56 (show GPR56 Antibodies) regulates oligodendrocyte development via interactions with Galpha12 (show GNA12 Antibodies)/13 and RhoA (show RHOA Antibodies)
S1pr2 (show S1PR2 Antibodies)/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Findings indicate a tumor suppressive role for G protein subunit alpha 13 (Galpha13) and rhoA (show RHOA Antibodies) GTP-binding protein (RhoA (show RHOA Antibodies)) in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL).
Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit (show POLG Antibodies) 13)
Upregulation of GNA13 expression increased the proliferation and tumorigenicity of gastric cancer.
Knockdown DDR1 (show DDR1 Antibodies) reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
RGS22 (show RGS22 Antibodies) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12 (show GNA12 Antibodies)/13.
Galpha13 Switch Region 2 Binds to the Talin Head Domain and Activates alphaIIbbeta3 Integrin in Human Platelets
GNA13 expression in breast cancer cells is regulated by post-transcriptional mechanisms involving miR (show MLXIP Antibodies)-31.
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (show F2R Antibodies)) at extracellular loop 2 (ECL2) controls G12 (show TCF3 Antibodies)/13 versus Gq G-proteins coupling specificity in response to thrombin (show F2 Antibodies) stimulation.
Our findings highlight the important role of miR (show MLXIP Antibodies)-29c in regulating CRC (show CALR Antibodies) EMT (show ITK Antibodies) via GSK-3b/b-catenin signaling by targeting GNA13 and PTP4A (show PTP4A2 Antibodies) and provide new insights into the metastatic basis of colorectal cancer
These results place Blk (show BLK Antibodies) upstream of the p190RhoGAP (show GRLF1 Antibodies)-RhoA (show RHOA Antibodies) pathway in Galpha13-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Antibodies)-triggered invasion.
results define Galpha13 as a switch regulator of myofiber reprogramming, implying that modulations of Galpha13 and its downstream effectors in skeletal muscle are a potential therapeutic approach to treating metabolic diseases.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 LARG (show ARHGEF12 Antibodies) interaction compared to the Galpha13 activation in the absence of LARG (show ARHGEF12 Antibodies).
GNA13 loss is associated with GC B (show NPR2 Antibodies)-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development.
Selective inhibition of G12 (show TCF3 Antibodies)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
findings identify a Galpha13-dependent pathway that exerts dual actions in suppressing growth and blocking dissemination of germinal centre B cells that is frequently disrupted in germinal centre B-cell-derived lymphoma
Direct Galpha13 binding to ITGB3 (show ITGB3 Antibodies) cytoplasmic domain regulates integrin outside-in signaling and thrombus formation in platelets.
Galpha (show SUCLG1 Antibodies) 13 is activated in sensory neurons mediated by lysophosphatidylinositol.
Galpha13 binding to VE-cadherin (show CDH5 Antibodies) mediates VE-cadherin (show CDH5 Antibodies) internalization and endothelial barrier disruption and inflammation.
Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
guanine nucleotide binding protein, alpha 13
, guanine nucleotide-binding protein subunit alpha-13
, Galpha 13a
, Galpha 13b
, G-protein alpha 13b
, guanine nucleotide binding protein (G protein), alpha 13
, guanine nucleotide-binding protein subunit alpha-13-like
, G-protein subunit alpha-13
, g alpha-13