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The differential expression of gpia and gpib in zebrafish suggests partition or divergence of gpi functions between the two duplicates.
Comparison of glucose phosphase isomerase (GPI) genes from several vertebrates suggests that GPIs are being subjected to purifying selection to maintain the polarity and volume of the protein, but not its charge.
low expression of alpha2beta1 integrin increased protein kinase B (AKT) activation and alpha-smooth muscle actin (alpha-SMA) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN) in myofibroblasts on fibrillar collagen.
Ceacam1 (show CEACAM1 ELISA Kits) is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 (show CEACAM1 ELISA Kits) induced moderate integrin aIIbb3-mediated functional defects.
HRG (show HRG ELISA Kits) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.
LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 (show MAPK1/3 ELISA Kits) and increased migration, favors myointimal thickening
IFN-gamma (show IFNG ELISA Kits) induces aberrant CD49b+ NK cell recruitment and pregnancy failure through regulating CX3CL1 (show CX3CL1 ELISA Kits).
alphaIIbbeta3 regulates Syk (show SYK ELISA Kits) through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk (show SYK ELISA Kits) activation and hemITAM phosphorylation by CLEC-2 (show CLEC1B ELISA Kits)
the collagen receptors DDR1 and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.
alpha2beta1 integrin contributes to the pathogenesis of retinopathy. We describe a newly identified role for alpha2beta1 integrin in mediating hypoxia-induced Muller cell VEGF-A (show VEGFA ELISA Kits) production.
required for the migration of memory CD4 (show CD4 ELISA Kits) T-cell precursors into their survival niches of the bone marrow
alpha2beta1 integrin is expressed on synovial Th17 cells from CIA (show NCOA5 ELISA Kits) mice. Its neutralization reduced inflammation, cartilage degradation, bone erosion, RANKL (show TNFSF11 ELISA Kits) & IL-17 (show IL17A ELISA Kits) levels, & the numbers of osteoclasts and TH17 cells.
The synonymous common variant, GPIA rs1126643, increases the long-term adverse events risk of CABG by augmenting GPIa protein expression and enhancing platelet aggregation function.
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 (show PECAM1 ELISA Kits) and P-Selectin (show SELP ELISA Kits) genes in the risk of recurrent IVF (show SCN5A ELISA Kits)-ET failures. The coexistence of these SNPs was associated with increased IVF (show SCN5A ELISA Kits)-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF (show SCN5A ELISA Kits)-ET failure, especially for younger women
Meta-analysis found that glycoprotein Ia (show MMRN1 ELISA Kits) C807T T allele or the TT genotype, the Ser (show SIGLEC1 ELISA Kits)-allele of HPA-3 and B allele of glycoprotein Ibalpha (show GP1BA ELISA Kits) variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.
Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 (show ITGB3 ELISA Kits) T1565C SNP, PECAM1 (show PECAM1 ELISA Kits) CTG - GTG (show GGT1 ELISA Kits) and SELP (show SEPP1 ELISA Kits) A/C polymorphisms with fetal growth restriction (FGR (show FGR ELISA Kits)).
The most common HPA (show HPSE ELISA Kits) genotypes among Saudis were HPA-1 (show HPSE ELISA Kits) a + b- (75%), HPA-2 (show HPSE2 ELISA Kits) a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE ELISA Kits)-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA (show HPSE ELISA Kits)-6 a + b- (100%) and HPA (show HPSE ELISA Kits)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE ELISA Kits) systems was (a), except in the HPA (show HPSE ELISA Kits)-15 system where the (b) allele was found in 52% of the subjects.
high miR (show MLXIP ELISA Kits)-128 expression suppressed osteosarcoma cell migration, invasion, and EMT (show ITK ELISA Kits) development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma.
Study identified a novel RANKL (show TNFSF11 ELISA Kits) function in the promotion of cell adhesion to type I collagen through the RANKL (show TNFSF11 ELISA Kits)-NF-kappa B (show NFKB1 ELISA Kits)-integrin alpha 2 pathway and found integrin alpha2 and RANKL (show TNFSF11 ELISA Kits) up-regulated in non small cell lung carcinoma.
High ITGA2 expression is associated with cervical cancer.
PDI-mediated disulfide bond exchange plays a pivotal role in the post-ligation phase of alphaIIbbeta3-mediated adhesion to fibrinogen, while this step in alphavbeta3-mediated adhesion is independent of disulfide exchange
Our results indicate that GpIa-807T and GpIIIa (show ITGB3 ELISA Kits)-PlA2 (show YWHAZ ELISA Kits) may be susceptibility alleles for in vitro fertilization implantation failure.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
both the gpIb-VWF (show VWF ELISA Kits) interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 ELISA Kits))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (show VWF ELISA Kits) is bound
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
, CD49 antigen-like family member B
, VLA-2 receptor, alpha 2 subunit
, VLA-2 subunit alpha
, collagen receptor
, integrin alpha-2
, platelet membrane glycoprotein Ia
, VLA2 receptor, alpha-2 subunit
, human platelet alloantigen system 5
, platelet antigen Br
, platelet glycoprotein GPIa
, very late activation protein 2 receptor, alpha-2 subunit
, VLA-2 alpha chain