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Our study elucidates the molecular mechanisms of miR (show MLXIP Proteins)-101/ITGA3 pathway in regulating nasopharyngeal carcinoma (NPC (show NPC1 Proteins))metastasis and angiogenesis, and the systemic delivery of miR (show MLXIP Proteins)-101 provides a potent evidence for the development of a novel microRNA-targeting anticancer strategy for NPC (show NPC1 Proteins) patients.
Results showed that ITGA3 was directly regulated by miR (show MLXIP Proteins)-199 family in head and neck squamous cell carcinoma cells (HNSCC). Its knockdown significantly inhibited cancer cell migration and invasion by HNSCC cells.
our studies clearly provide evidence that aberrant expression of sFRP2 (show SFRP2 Proteins) can contribute to the invasive and metastatic potential for osteosarcoma.
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5 (show LAMA5 Proteins)) were significantly inhibited by curcumin at messenger RNA and protein levels.
High ITGA3 expression is associated with bladder cancer.
these findings identify CD151 (show CD151 Proteins) and its interactions with integrins a3 and a6 as potential therapeutic targets for inhibiting stemness-driving mechanisms and stem cell populations in Glioblastoma.
Expression of the alpha3-Integrin splice variants in the brain
the role of the CD151 (show CD151 Proteins)-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion.
In high grade DCIS, when stratified according to the HER2 (show ERBB2 Proteins) status, in the HER2 (show ERBB2 Proteins)-negative subgroup, CD151 (show CD151 Proteins) assessed in combination with alpha3beta1 was significantly correlated with prognosis.
Data show that CD151 (show CD151 Proteins) protein (CD151 (show CD151 Proteins))-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR (show EGFR Proteins)) to drive tumor cell motility.
formation of CD151 (show CD151 Proteins)-integrin complex was likely to be a prerequisite for CD151 (show CD151 Proteins)-induced angiogenesis and signaling pathways
K63-linked polyubiquitination of Akt (show AKT1 Proteins) plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required for ureteric bud development and may represent a novel mechanism whereby integrins regulate signaling pathways.
alpha3beta1-dependent alternative polyadenylation of MMP-9 (show MMP9 Proteins) mRNA occurs through a signaling pathway that involves extracellular signal-regulated kinase/mitogen-activated protein kinases.
NR1, a novel antioxidant, ameliorated glucose-induced impaired podocyte adhesive capacity and subsequent podocyte depopulation partly through a3b1 integrin upregulation.
These findings demonstrate a prominent role for alpha3beta1 in immortalized/transformed keratinocytes in regulating fibulin-2 (show FBLN2 Proteins) and other genes that promote matrix remodeling and invasion.
integrin alpha3beta1 has a role in basement membrane stability through fibulin-2 (show FBLN2 Proteins) induction, both in neonatal skin and in adult wounds
GPR56 (show GPR56 Proteins) functions together with alpha3beta1 integrin in regulating cerebral cortical development.
Results indicate that the basement membrane extract (BME) embedment of islets can up-regulate the expression of alpha3 integrin and its signal transduction, which may improve islet viability.
During myoblast fusion integrin alpha3 associates with integrin beta1 and ADAM12 (show ADAM12 Proteins), and also CD9 (show CD9 Proteins) and CD81 (show CD81 Proteins).
overexpression of mesangial integrin alpha1 and podocyte vimentin (show VIM Proteins) and integrin alpha3 may be important features of glomerular Alport disease
The C-terminal region of NELL1 (show NELL1 Proteins) mediates osteoblastic cell adhesion through integrin alpha3beta1
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
CD49 antigen-like family member C
, VLA-3 subunit alpha
, antigen identified by monoclonal antibody J143
, galactoprotein B3
, integrin alpha-3
, very late activation protein 3 receptor, alpha-3 subunit
, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
, integrin alpha 3 subunit
, Galactoprotein B3
, Integrin alpha-3
, integrin alpha 3
, integrin alpha-3-like
, VLA-3 alpha 3
, VLA-3 receptor, alpha 3 subunit