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Caspase-11 (show CASP4 Proteins) targets cofilin (show CFL1 Proteins) via the RhoA GTPase, whereas caspase-1 (show CASP1 Proteins) engages the Slingshot phosphatase
SSH1L knockdown, like S1P (show S1PR1 Proteins) treatment, increased cardiomyocyte survival and preserved mitochondrial integrity after oxidative stress
EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.
PDGF (show PDGFA Proteins) activates SSH1L in VSMC by a mechanism that involves Nox1 (show NOX1 Proteins)-mediated oxidation of 14-3-3 (show YWHAQ Proteins) and Ser (show SIGLEC1 Proteins)-834 SSH1L auto-dephosphorylation.
Knockdown of SSH1 expression by RNA interference significantly suppressed stress fiber formation in C2C12 myoblast cells, indicating a role for SSH1 in stress fiber formation or stabilization in cells.
SSH1 binds to gelsolin (show GSN Proteins) via actin filaments in the cytosolic fraction. Gelsolin (show GSN Proteins) promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.
the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin (show CFL1 Proteins)-phosphatase activity of SSH1
Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 (show CFL1 Proteins) signal pathway is associated positively in PC with cell migration.
Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics.
The association of IRS4 (show IRS4 Proteins) with SSH1 contributes to localized activation of cofilin (show CFL1 Proteins) in membrane protrusions.
Slingshot 1 downregulation in neuronal cells inactivates cofilin (show CFL1 Proteins) to facilitate HSV-1 replication.
Thus this study provides evidence for a novel role of LIMK1 (show LIMK1 Proteins) and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation.
Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells.
A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils.
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, SSH-like protein 1
, protein phosphatase Slingshot homolog 1
, slingshot 1L
, slingshot-like 1
, slingshot homolog 1