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The rare alleles of specific single nucleotide polymorphisms within the FOLR1 (show FOLR1 Proteins), FOLR2 (show FOLR2 Proteins), and FOLR3 genes were statistically significant for association with meningomyelocele.
This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants\\\\; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively.
folate receptor gamma
, folate receptor 3 (gamma)