Browse our Solute Carrier Family 19, Member 3 Proteins (Slc19a3)

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Solute Carrier Family 19, Member 3 Proteins (Slc19a3)
On www.antibodies-online.com are 4 Solute Carrier Family 19, Member 3 (Slc19a3) Proteins from 3 different suppliers available. Additionally we are shipping Solute Carrier Family 19, Member 3 Antibodies (34) and many more products for this protein. A total of 43 Solute Carrier Family 19, Member 3 products are currently listed.
Synonyms:
A230084E24Rik, AI788884, BBGD, MGC52872, MGC89434, si:dkey-223n17.4, slc19a3, THMD2, ThTr2
list all proteins Gene Name GeneID UniProt
Slc19a3 80704 Q9BZV2
Rat Slc19a3 Slc19a3 316559  
Slc19a3 80721 Q99PL8

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Solute Carrier Family 19, Member 3 Proteins (Slc19a3) by Origin

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More Proteins for Solute Carrier Family 19, Member 3 Interaction Partners

Human Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

  1. Genetic variations in SLC19A3 play an important role in the pathogenesis of severe diabetic retinopathy and nephropathy and may explain why some individuals with type 1 diabetes are less prone than others to develop microvascular complications.

  2. Genetic screening of SLC19A3 mutation is crucial to diagnosis autosomal recessive biotin-thiamine-responsive basal ganglia disease in asymptomatic relatives presenting with unexplained subacute encephalopathy and abnormal movements.

  3. The direct binding and activation of SLC19A3 expression by HIF-1alpha (show HIF1A Proteins) during hypoxic stress

  4. The mutation of SLC19A3 is related to Biotin-thiamine-responsive basal ganglia disease.

  5. Species differences in the substrate specificity of THTR-2 between human and mouse orthologues were observed.

  6. large genomic deletions occur in the regulatory region of SLC19A3 in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy

  7. Genetic variation in the SLC19A3 thiamine transporter at 2:228563818T/C may make a modest contribution towards the genetic susceptibility to alcohol dependence syndrome.

  8. This study provided evidence that biotin-thiamine-responsive basal ganglia disease is the result of SLC19A2 mutation.

  9. TM4SF4 (show TM4SF4 Proteins) interacts with hTHTR-2 and influences the physiological function of the thiamine transporter in human intestinal epithelial cells.

  10. These studies demonstrate that the human intestinal thiamine uptake is adaptively regulated by the extracellular substrate level via transcriptional regulation of the THTR-2 system, and that SP1 (show PSG1 Proteins) transcriptional factor is involved in this regulation.

Mouse (Murine) Solute Carrier Family 19, Member 3 (Slc19a3) interaction partners

  1. THTR-2 is required for normal uptake of thiamin in the intestine and can fulfill normal levels of uptake in conditions associated with THTR-1 (show DDA1 Proteins) dysfunction.

  2. Pancreatic beta cells and islets take up thiamine by a regulated THTR1 (show DDA1 Proteins)/2-mediated process.

Solute Carrier Family 19, Member 3 (Slc19a3) Protein Profile

Protein Summary

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD)\; a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.

Alternative names and synonyms associated with Solute Carrier Family 19, Member 3 (Slc19a3)

  • solute carrier family 19, member 3 (slc19a3)
  • solute carrier family 19, member 3 (SLC19A3)
  • solute carrier family 19, member 3b (slc19a3b)
  • solute carrier family 19, member 3 (LOC100230080)
  • solute carrier family 19 (thiamine transporter), member 3 (SLC19A3)
  • solute carrier family 19 (thiamine transporter), member 3 (Slc19a3)
  • solute carrier family 19, member 3 (Slc19a3)
  • A230084E24Rik protein
  • AI788884 protein
  • BBGD protein
  • MGC52872 protein
  • MGC89434 protein
  • si:dkey-223n17.4 protein
  • slc19a3 protein
  • THMD2 protein
  • ThTr2 protein

Protein level used designations for Slc19a3

solute carrier family 19, member 3 , thiamine transporter 2 , thiamine transporter 2-like , thTr-2 , solute carrier family 19 (sodium/hydrogen exchanger), member 3

GENE ID SPECIES
379156 Xenopus laevis
424792 Gallus gallus
448431 Xenopus (Silurana) tropicalis
470667 Pan troglodytes
549052 Xenopus (Silurana) tropicalis
556920 Danio rerio
709554 Macaca mulatta
100230080 Taeniopygia guttata
100341170 Oryctolagus cuniculus
100445161 Pongo abelii
80704 Homo sapiens
316559 Rattus norvegicus
486151 Canis lupus familiaris
537280 Bos taurus
80721 Mus musculus
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