Browse our SLC1A2 Proteins (SLC1A2)

Full name:
Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 Proteins (SLC1A2)
On www.antibodies-online.com are 5 Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) Proteins from 3 different suppliers available. Additionally we are shipping SLC1A2 Antibodies (60) and SLC1A2 Kits (13) and many more products for this protein. A total of 83 SLC1A2 products are currently listed.
Synonyms:
1700091C19Rik, 2900019G14Rik, AI159670, CG3159, dEaat2, Dmel\\CG3159, Eaat, eaat2, fj34b12, GB16377, Glt, GLT-1, GLT1, MGLT1, slc1a2, wu:fj34b12, zgc:65897
list all proteins Gene Name GeneID UniProt
SLC1A2 29482 P31596
SLC1A2 6506 P43004
SLC1A2 20511 P43006

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SLC1A2 Proteins (SLC1A2) by Origin

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More Proteins for SLC1A2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) interaction partners

  1. Data suggest that EAAT2 functions as a taurine transporter in vivo and is physiologically required for the sensory perception of specific environmental molecules.

  2. Taurine and aspartate are transported with similar K(m) and relative efficacy and behave as mutually competitive inhibitors; dEAAT2 is actually an aspartate/taurine transporter

Human Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) interaction partners

  1. This study provides further evidence for SLC1A2 mutations in epileptic encephalopathies and suggests a gain-of-function mechanism for this rather severe presentation.

  2. GLT1 was demonstrated by luciferase assay to be a target of miR (show MLXIP Proteins)-31-5p and miR (show MLXIP Proteins)-200c-3p, and both its mRNA and protein (immunohistochemistry) significantly decreased with age in liver biopsies and in hepatic centrilobular zone, respectively

  3. Mutations in SLC1A2 and CACNA1A (show CACNA1A Proteins) Are Important Causes of Epileptic Encephalopathies

  4. The results of this study suggested SLC1A2 rs3794087 may decrease the risk for Parkinson's disease in a Chinese cohort, but do not support a role in the susceptibility to amyotrophic lateral sclerosis or multiple system atrophy.

  5. that Abeta1-42 oligomers could cause disturbances in insulin (show INS Proteins)/Akt (show AKT1 Proteins)/EAAT signaling in astrocytes

  6. This study showed a lack of association between of SLC1A2 rs3794087 with the risk for essential tremor.

  7. Results suggest that genetic variation (rs4354668 and its haplotypes) in SLC1A2 may be involved in impaired executive function, which adds to the current body of knowledge regarding the risk of schizophrenia and the impairment of cognitive performance

  8. SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful negative regulators of the excitatory glutamate (show GRIN1 Proteins) transporters EAAT1 (show SLC1A3 Proteins) and EAAT2.

  9. PPARgamma (show PPARG Proteins) agonist pioglitazone has a role in modulating EAAT2 expression in glioma cells

  10. Two recurrent SLC1A2 missense variants and one recurrent 5'-untranslated region variant were found to be associated with susceptibility to the development of bipolar disorder and schizophrenia.

Mouse (Murine) Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) interaction partners

  1. Mutation of the caspase-3 (show CASP3 Proteins) cleavage site in the astroglial glutamate transporter (show SLC1A1 Proteins) EAAT2 delays disease progression and extends lifespan in the SOD1 (show SOD1 Proteins)-G93A mouse model of amyotrophic lateral sclerosis

  2. The upregulation of GLT-1 induced by transplanted neural precursor cells was found to rely on the secretion of VEGF by neural precursor cells

  3. We demonstrate that the R6/1 transgenic mouse model of HD has lower basal levels of cystine, and showed depressive-like behaviors in the forced-swim test. Administration of NAC reversed these behaviors. This effect was blocked by co-administration of the system xc(-) and GLT-1 inhibitors CPG and DHK, showing that glutamate transporter activity was required for the antidepressant effects of NAC

  4. Consistent with glutamate (show GRIN1 Proteins) dysregulation, analysis of neurons reveal changes in morphology including a reduction in dendritic spines, VGlut1 and NeuN (show RBFOX3 Proteins) immunoreactivity

  5. A significant initial increase in dorsal hippocampal GLT1 immunoreactivity and protein levels were observed 1day post epilepsy and followed by a marked downregulation at 4 and 7days post epilepsy with a return to near control levels by 30days post epilepsy.

  6. These results demonstrate that focal restoration of GLT1 expression in the superficial dorsal horn is a promising target for treating chronic neuropathic pain following SCI.

  7. Lipid raft integrity, ensured by DHCR24 (show DHCR24 Proteins), plays a crucial role in the ischemic brain by guaranteeing EAAT2-mediated uptake of glutamate (show GRIN1 Proteins) excess.

  8. Findings suggest that focal restoration of glutamate transporter (show SLC1A1 Proteins) 1,expression in astrocytes of the cervical spinal cord using adeno (show ADORA2A Proteins)-associated virus delivery is not an effective therapy for amyotrophic lateral sclerosis.

  9. we have demonstrated for the first time that DOR receptor activation induces astrocytic expression of EAAT1 (show SLC1A3 Proteins) and EAAT2

  10. neuronal GLT-1 but not astrocytic GLT-1 contributed significantly to glutamate uptake. astrocytic GLT-1 performs critical functions required for normal weight gain, resistance to epilepsy, and survival.

Zebrafish Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) interaction partners

  1. Disruption of Eaat2b, a glutamate transporter (show SLC1A1 Proteins), results in abnormal motor behaviors in developing zebrafish.

SLC1A2 Protein Profile

Protein Summary

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.

Alternative names and synonyms associated with SLC1A2

  • Excitatory amino acid transporter 2 (Eaat2)
  • excitatory amino acid transporter 2 (Eaat-2)
  • excitatory amino acid transporter 2 (EAAT2)
  • excitatory amino acid transporter 2 (VDBG_06180)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2 (EUBELI_01747)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Trebr_0139)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2 (LOC100218134)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2 (Slc1a2)
  • solute carrier family 1 (glial high affinity glutamate transporter), member 2b (slc1a2b)
  • 1700091C19Rik protein
  • 2900019G14Rik protein
  • AI159670 protein
  • CG3159 protein
  • dEaat2 protein
  • Dmel\\CG3159 protein
  • Eaat protein
  • eaat2 protein
  • fj34b12 protein
  • GB16377 protein
  • Glt protein
  • GLT-1 protein
  • GLT1 protein
  • MGLT1 protein
  • slc1a2 protein
  • wu:fj34b12 protein
  • zgc:65897 protein

Protein level used designations for SLC1A2

CG3159-PA , CG3159-PC , CG3159-PD , Eaat2-PA , Eaat2-PC , Eaat2-PD , excitatory amino acid transporter 2 , sodium-dependent excitatory amino acid transporter 2 , glutamate transporter Am-EAAT , solute carrier family 1 (glial high affinity glutamate transporter), member 2 , excitatory amino acid transporter 2-like , high affinity glucose transporter , sodium-dependent glutamate/aspartate transporter 2 , excitotoxic amino acid transporter 2 , glutamate/aspartate transporter II , glial high affinity glutamate transporter , solute carrier family 1 member 2 , solute carrier family 1, member 2 , glutamate transporter

GENE ID SPECIES
33247 Drosophila melanogaster
406113 Apis mellifera
443247 Ovis aries
9534921 Verticillium alfalfae VaMs.102
450180 Pan troglodytes
541119 Bos taurus
574358 Macaca mulatta
7958042 Eubacterium eligens ATCC 27750
10578616 Treponema brennaborense DSM 12168
100009860 Monodelphis domestica
100173577 Pongo abelii
100218134 Taeniopygia guttata
100391501 Callithrix jacchus
100590219 Nomascus leucogenys
29482 Rattus norvegicus
6506 Homo sapiens
20511 Mus musculus
423156 Gallus gallus
403750 Canis lupus familiaris
335836 Danio rerio
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