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Human Polyclonal SLC22A6 Primary Antibody for FACS, IHC (p) - ABIN653184
Hadrup, Pedersen, Skov, Hansen, Berthelsen, Kongsbak, Boberg, Dybdahl, Hass, Frandsen, Vinggaard: Perfluorononanoic acid in combination with 14 chemicals exerts low-dose mixture effects in rats. in Archives of toxicology 2016
SLC22A6 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
this is the first demonstration that Nedd4-1 (show NEDD4 Antibodies) regulates hOAT1 ubiquitination, expression, and transport activity through its WW2 and WW3 domains
both Nedd4-1 (show NEDD4 Antibodies) and Nedd4-2 (show NEDD4L Antibodies) are important regulators for hOAT1 ubiquitination, expression, and function
Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (show KCNK3 Antibodies)/OAT3 (show SLC22A8 Antibodies).
OAT1 (show KCNK3 Antibodies) and NaDC3 (show SLC13A3 Antibodies) in the basolateral membrane and OAT4 (show SLC22A9 Antibodies) in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate.
BCL6 (show BCL6 Antibodies) constitutes a promising candidate gene for the regulation of human OAT1 (show KCNK3 Antibodies) transcription
Clopidogrel/clopidogrel carboxylate are weak inhibitors of OAT1 (show KCNK3 Antibodies).
The results confirmed that OAT1 (show KCNK3 Antibodies), OAT3 (show SLC22A8 Antibodies), OCT2, MATE1 (show SLC47A1 Antibodies), and MATE2-K (show SLC47A2 Antibodies) were coexpressed in tubular epithelial cells.
transport of xanthurenic acid by OAT1 (show KCNK3 Antibodies) and OAT3 (show SLC22A8 Antibodies)
PKC (show PRRT2 Antibodies) isoform PKCalpha (show PKCa Antibodies) was responsible for OAT1 (show KCNK3 Antibodies) ubiquitination.
An Organic Anion Transporter 1 (OAT1)-centered Metabolic Network.
Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 and OAT3 (show SLC22A8 Antibodies)).
OAT1-deficient mice showed abnormal LTP (show SCP2 Antibodies) and higher spine numbers but with a much lesser maturity extent.
At the protein level, mOat3 (show SLC22A8 Antibodies) and mOat1 exhibit sex-dependent expression with an opposite pattern; mOat3 (show SLC22A8 Antibodies) is female dominant due to androgen inhibition, while mOat1 is male dominant due to androgen stimulation.
Oat1 potentially plays a major role in the rate limiting step in the uptake and excretion of putative toxic metabolites
acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1.
functional differences in the relative importance of OAT1 and OAT3 (show SLC22A8 Antibodies) in antiviral handling in developing and mature tissue
the ontogenic pattern of expression of OAT1 and OAT3 (show SLC22A8 Antibodies) in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus
Although all cysteine mutants of mOAT1 were sensitive to the inhibition by PCMBS, C49A (show IL24 Antibodies) was less sensitive than the wild-type mOAT1, suggesting that the modification of Cys49 may play a role in the inhibition of mOAT1 by PCMBS.
analysis of physiological substrates of OAT1
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene.
solute carrier family 22 (organic anion transporter), member 6
, solute carrier family 22 member 6
, Solute carrier family 22 member 6
, organic anion transporter 1
, renal organic anion transporter 1
, putative organic anion transporter
, PAH transporter
, para-aminohippurate transporter
, kidney-specific transport protein
, novel kidney transcript
, organic cationic transporter-like 1
, solute carrier family 22, member 6
, organic cation transporter 1-B
, renal organic anion transporter 1-B
, solute carrier family 22 member 6-B