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the molecular cloning from human HEVEC of a 2.9-kb cDNA encoding SLC26A7, a novel member of the SLC26 (solute carrier 26) sulfate/anion exchanger family
In human kidney SLC26A6 (show SLC26A6 ELISA Kits) and A7 have a distinct, partially overlapping expression in distal segments of nephrons. The distribution partly differs from that found previously in rodent kidneys.
The trafficking to the cell surface suggests novel functional upregulation of SLC26A7 in states that are associated with hypokalemia or increased medullary tonicity.
Slc26a1 (show SLC26A1 ELISA Kits), Slc26a6 (show SLC26A6 ELISA Kits) and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
Slc26a7 chloride channel (show CLCA1 ELISA Kits) activity and localization in mouse Reissner's membrane epithelium
SLC26A7 is a basolateral Cl(-)/HCO(3)(-) exchanger in gastric parietal cells and possibly plays a major role in gastric acid secretion
findings reveal that SLC26A7 functions as a unique Cl(-) channel that is regulated by intracellular H(+)
Slc26a7 is expressed in the proximal tubule and thick ascending limb of the loop of Henle, and it may therefore contribute to anion transport in these nephron segments
CAII (show CA2 ELISA Kits) deficiency results in a significant decrease in the gene and protein expression of bicarbonate transport proteins from Slc26 gene family - Slc26a4 (pendrin (show SLC26A4 ELISA Kits)) and Slc26a7.
Suggest that the increase in Slc26a7 expression caused by deletion of AE1 (show SLC4A1 ELISA Kits) represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney.
SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.
solute carrier family 26, member 7
, anion exchange transporter
, Anion exchange transporter
, solute carrier family 26 member 7
, anion exchange transporter-like
, sulfate anion transporter
, anion exchanger Slc26a7